Substance
ID:182471
Names and Identifiers
IUPAC Traditional name
(+)-thalidomide
IUPAC name
2-[(3S)-2,6-dioxopiperidin-3-yl]-2,3-dihydro-1H-isoindole-1,3-dione
Synonyms
S(-)-2-(2,6-Dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione(-)-Thalidomide
Properties
Safety Information
German water hazard class
3
GHS Signal Word
Danger
GHS Precautionary statements
P201-P308+P313
RTECS
TI4925050
GHS Pictograms
Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, category 2
Eye irritation, category 2
Skin sensitisation, category 1
Specific Target Organ Toxicity – Single exposure, category 3
Respiratory sensitization, category 1
Germ cell mutagenicity, categories 1A,1B,2
Carcinogenicity, categories 1A,1B,2
Reproductive toxicity, categories 1A,1B,2
Specific Target Organ Toxicity – Single exposure, categories 1,2
Specific Target Organ Toxicity – Repeated exposure, categories 1,2
Aspiration Hazard, category 1
Safety Statements
53-36/37/39-45
European Hazard Symbols
Toxic (T)Risk Statements
61-22
Personal Protective Equipment
Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
Packing Group
2
RID/ADR
UN 2811 6.1/PG 2
UN Number
2811
GHS Hazard statements
H302-H360
Hazard Class
6.1
Physical Property
Solubility
H2O: insoluble
DMSO: soluble
ethanol: insoluble
Apperance
white solid
Optical Rotation
[α]23/D -62.6°, c = 2 in DMF(lit.)
Product Information
Purity
>98%
Pharmacology Properties
Gene Information
human ... LITAF(9516), TNF(7124)mouse ... Nos2(18126)rat ... Nos1(24598)
Molecule Details
Biochem/physiol Actions
(-)-Thalidomide selectively inhibits biosynthesis of tumor necrosis factor α (TNF-α); inhibitor of angiogenesis. (S)-Thalidomide is a teratogenic enatiomer.
(-)-Thalidomide selectively inhibits biosynthesis of tumor necrosis factor α (TNF-α); inhibitor of angiogenesis. (S)-Thalidomide is a teratogenic enatiomer.
Molecular Spectra
No Data Available
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References
No Data Available
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