Substance
ID:1824213
Names and Identifiers
Synonyms
pergolide
International Nonproprietary Name (INN)
pergolidapergolidepergolidum
IUPAC name
(2R,4R,7R)-4-[(methylsulfanyl)methyl]-6-propyl-6,11-diazatetracyclo[7.6.1.0²,⁷.0¹²,¹⁶]hexadeca-1(16),9,12,14-tetraene
IUPAC Traditional name
(2R,4R,7R)-4-[(methylsulfanyl)methyl]-6-propyl-6,11-diazatetracyclo[7.6.1.0^{2,7}.0^{12,16}]hexadeca-1(16),9,12,14-tetraene
Registration numbers
PubChem CID
CAS Number
KEGG ID
LINCS Database
Reaxys Registry
ACToR Database
BKMS React Database
BRENDA Database
BRENDA Ligand Database
CHEMBL
CompTox Database
SABIO-RK Database
SureChEMBL Database
HMDB Database
Wikipedia Title
NMRShiftDB Database
Patent number
DrugBank ID
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BindingDB Database
KEGG DRUG Database
Reactom Database
CHEBI ID
PubChem SID
Properties
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Molecule Details
A diamine that is ergoline in which the beta-hydrogen at position 8 is replaced by a (methylthio)methyl group and the hydrogen attached to the piperidine nitrogen (position 6) is replaced by a propyl group. A dopamine D2 receptor agonist which also has D1 and D2 agonist properties, it is used as the mesylate salt in the management of Parkinson's disease, although it was withdrawn from the U.S. and Canadian markets in 2007 due to an increased risk of cardiac valve dysfunction.
Molecular Spectra
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References
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