Substance
ID:182396
Names and Identifiers
IUPAC Traditional name
haloperidol
IUPAC name
4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-1-(4-fluorophenyl)butan-1-one
Synonyms
4-[4-(4-Chlorophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)-1-butanone4-[4-(p-Chlorophenyl)-4-hydroxypiperidino]-4′-fluorobutyrophenoneHaloperidol4-[4-(4-Chlorophenyl)-4-hydroxypiperidino]-4′-fluorobutyrophenone
Properties
Physical Property
Apperance
white powder
Solubility
0.1 M HCl: soluble3 mg/mL
ethanol: soluble
DMSO: soluble
H2O: insoluble
45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: soluble0.39 mg/mL
Safety Information
German water hazard class
3
RID/ADR
UN 2811 6.1/PG 3
Packing Group
3
GHS Pictograms
Respiratory sensitization, category 1
Germ cell mutagenicity, categories 1A,1B,2
Carcinogenicity, categories 1A,1B,2
Reproductive toxicity, categories 1A,1B,2
Specific Target Organ Toxicity – Single exposure, categories 1,2
Specific Target Organ Toxicity – Repeated exposure, categories 1,2
Aspiration Hazard, category 1
Acute toxicity (oral, dermal, inhalation), categories 1,2,3
GHS Hazard statements
H301-H315-H317-H319-H335-H361
European Hazard Symbols
Toxic (T)GHS Precautionary statements
P261-P280-P301+P310-P305+P351+P338
Risk Statements
60-61-25-36/37/38-43
Safety Statements
53-26-36/37/39-45
GHS Signal Word
Danger
UN Number
2811
Hazard Class
6.1
Pharmacology Properties
Gene Information
human ... ABCB1(5243), ADRA1A(148), ADRA2A(150), ADRA2C(152), CHRM1(1128), DRD2(1813), DRD3(1814), DRD4(1815), EBP(10682), HRH1(3269), HTR2A(3356), HTR2C(3358), HTR7(3363), KCNH1(3756), KCNH2(3757), PRNP(5621)rat ... Adra1a(29412), Adra2a(25083), Chrm1(25229), Chrm2(81645), Drd1a(24316), Drd2(24318), Drd3(29238), Drd4(25432), Hrh1(24448), Htr1a(24473), Htr1b(25075), Htr2a(29595), Htr2c(25187), Oprs1(29336), Slc6a3(24898), Slc6a4(25553)
Molecule Details
Biochem/physiol Actions
Butyrophenone antipsychotic; D2, D3, and D4 dopamine receptor antagonist.
Other Notes
Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. H1512.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.
Butyrophenone antipsychotic; D2, D3, and D4 dopamine receptor antagonist.
Other Notes
Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. H1512.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.
Molecular Spectra
No Data Available
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References
No Data Available
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