Substance
ID:182368
Names and Identifiers
IUPAC name
2-(3-carboxy-2-acetamidopropanamido)pentanedioic acid
IUPAC Traditional name
2-(3-carboxy-2-acetamidopropanamido)pentanedioic acid
Synonyms
N-Acetyl-Asp-GluSpaglumic acidNAAG
Properties
Safety Information
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Storage Temperature
-20°C
GHS Pictograms
Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, category 2
Eye irritation, category 2
Skin sensitisation, category 1
Specific Target Organ Toxicity – Single exposure, category 3
GHS Hazard statements
H315-H319-H335
German water hazard class
3
Safety Statements
26-36
GHS Precautionary statements
P261-P305+P351+P338
European Hazard Symbols
Irritant (Xi)GHS Signal Word
Warning
Risk Statements
36/37/38
Pharmacology Properties
Gene Information
human ... GRIN1(2902), GRIN2A(2903), GRIN2B(2904), GRIN2C(2905), GRIN2D(2906), GRIN3A(116443), GRIN3B(116444), GRINA(2907), GRM3(2913)mouse ... GRIN1(14810), GRIN2A(14811), GRIN2B(14812), GRIN2C(14813), GRIN2D(14814), GRIN3A(242443), GRIN3B(170483), GRINA(66168), GRM3(108069)rat ... GRIN1(24408), GRIN2A(24409), GRIN2B(24410), GRIN2C(24411), GRIN2D(24412), GRIN3A(191573), GRIN3B(170796), GRINA(266668), GRM3(24416)
Product Information
Purity
≥97% (TLC)
Physical Property
Optical Rotation
[α]22/D -34.5°, c = 1.1 in H2O(lit.)
Solubility
H2O: soluble50 mg/mL
Apperance
white powder
Molecule Details
Amino Acid Sequence
NAc-Asp-Glu
Caution
Store desiccated.
Biochem/physiol Actions
Endogenous neurotransmitter localized to neurons with high affinity for metabotropic glutamate receptors, mGluR3. It is an antagonist at NMDA receptors. Catabolized by carboxypeptidase II, which is expressed on astrocyte membranes, to N-acetylaspartate and glutamate.
Other Notes
Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. A5930.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.
NAc-Asp-Glu
Caution
Store desiccated.
Biochem/physiol Actions
Endogenous neurotransmitter localized to neurons with high affinity for metabotropic glutamate receptors, mGluR3. It is an antagonist at NMDA receptors. Catabolized by carboxypeptidase II, which is expressed on astrocyte membranes, to N-acetylaspartate and glutamate.
Other Notes
Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. A5930.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.
Molecular Spectra
No Data Available
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References
No Data Available
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