Substance
ID:182315
Names and Identifiers
IUPAC Traditional name
flurbiprofen
IUPAC name
2-(3-fluoro-4-phenylphenyl)propanoic acid
Synonyms
Flurbiprofen氟比洛芬(±)-2-氟-α-甲基-4-联苯基乙酸L-790,330
Properties
Pharmacology Properties
Gene Information
human ... ALB(213), APP(351), CYP1A2(1544), CYP2C9(1559)rat ... Ptgs1(24693)
Safety Information
RID/ADR
UN 2811 6.1/PG 3
GHS Signal Word
Danger
UN Number
2811
GHS Hazard statements
H301
Safety Statements
36/37/39-45
German water hazard class
3
Packing Group
3
European Hazard Symbols
Toxic (T)Risk Statements
25
RTECS
DU8341000
Hazard Class
6.1
GHS Pictograms
Acute toxicity (oral, dermal, inhalation), categories 1,2,3
Personal Protective Equipment
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
GHS Precautionary statements
P301+P310
Physical Property
Melting Point
110-112 °C(lit.)
Molecule Details
Application
Flurbiprofen is a nonsteroidal anti-inflammatory agent (NSAIA) with antipyretic, analgesic, and antifungal activity. Oral formulations of flurbiprofen may be used to treat rheumatoid arthritis, osteoarthritis and anklylosing spondylitis. Flurbiprofen is also used topically during ocular surgery to prevent or reduce intraoperative miosis. Flurbiprofen is structurally and pharmacologically related to ibuprofen. It is used to study the pathophysiological steps of NSAID enteropathy in the rat1 and the biotransformation of flurbiprofen by Cunninghamella species2.
Biochem/physiol Actions
Fluibiprofen is a cyclooxygenase (COX) inhibitor, which is an enzyme responsible for the conversion of arachidonic acid to prostaglandin G2 (PGG2) and PGG2 to prostaglandin H2 (PGH2) in the prostaglandin synthesis pathway. This decreases the prostaglandins which cause inflammation, pain, swelling and fever. Flurbiprofen inhibits the activity of both COX-1 and -2. The S enantiomer inhibits prostaglandin synthesis and has both anti-inflammatory and analgesic activity, while the R enantiomer does not inhibit prostaglandin synthesis and displays only analgesic activity.
Flurbiprofen is a nonsteroidal anti-inflammatory agent (NSAIA) with antipyretic, analgesic, and antifungal activity. Oral formulations of flurbiprofen may be used to treat rheumatoid arthritis, osteoarthritis and anklylosing spondylitis. Flurbiprofen is also used topically during ocular surgery to prevent or reduce intraoperative miosis. Flurbiprofen is structurally and pharmacologically related to ibuprofen. It is used to study the pathophysiological steps of NSAID enteropathy in the rat1 and the biotransformation of flurbiprofen by Cunninghamella species2.
Biochem/physiol Actions
Fluibiprofen is a cyclooxygenase (COX) inhibitor, which is an enzyme responsible for the conversion of arachidonic acid to prostaglandin G2 (PGG2) and PGG2 to prostaglandin H2 (PGH2) in the prostaglandin synthesis pathway. This decreases the prostaglandins which cause inflammation, pain, swelling and fever. Flurbiprofen inhibits the activity of both COX-1 and -2. The S enantiomer inhibits prostaglandin synthesis and has both anti-inflammatory and analgesic activity, while the R enantiomer does not inhibit prostaglandin synthesis and displays only analgesic activity.
Molecular Spectra
No Data Available
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References
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