Substance
ID:182311
Names and Identifiers
Synonyms
DTICDacarbazine5-(3,3-Dimethyl-1-triazenyl)imidazole-4-carboxamide
IUPAC name
5-[(1E)-dimethyltriaz-1-en-1-yl]-1H-imidazole-4-carboxamide
IUPAC Traditional name
dacarbazine
Properties
Safety Information
GHS Signal Word
Danger
GHS Pictograms
Respiratory sensitization, category 1
Germ cell mutagenicity, categories 1A,1B,2
Carcinogenicity, categories 1A,1B,2
Reproductive toxicity, categories 1A,1B,2
Specific Target Organ Toxicity – Single exposure, categories 1,2
Specific Target Organ Toxicity – Repeated exposure, categories 1,2
Aspiration Hazard, category 1
Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, category 2
Eye irritation, category 2
Skin sensitisation, category 1
Specific Target Organ Toxicity – Single exposure, category 3
Storage Temperature
2-8°C
Safety Statements
53-36/37/39-45
European Hazard Symbols
Toxic (T)German water hazard class
3
RTECS
NI3950000
GHS Precautionary statements
P201-P261-P280-P305+P351+P338-P308+P313
GHS Hazard statements
H312-H315-H319-H332-H335-H350
Personal Protective Equipment
Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
Risk Statements
45-46-20/21/22-36/37/38
Molecule Details
Application
Dacarbazine is a triazine antineoplastic agent that is used for DNA methylation via formation of methyl adducts. It is used to treat metastatic malignant melanomas and Hodgkin′s when used in combination with other antineoplastic agents. It is used to induce apoptosis in human cells1. It has been used to induce hepatotoxicity in mice2.
Biochem/physiol Actions
Dacarbazine has significant activity against melanomas. It is a synthetic analog of naturally occurring purine precursor 5-amino-1H-imidazole-4-carboxamide (AIC). Dacarbazine appears to exert cytotoxic effects by acting as an alkylating agent, by inhibiting DNA synthesis as a purine analog, and by inducing apoptosis1. Dacarbazine is not cell cycle-phase specific.
Dacarbazine is a triazine antineoplastic agent that is used for DNA methylation via formation of methyl adducts. It is used to treat metastatic malignant melanomas and Hodgkin′s when used in combination with other antineoplastic agents. It is used to induce apoptosis in human cells1. It has been used to induce hepatotoxicity in mice2.
Biochem/physiol Actions
Dacarbazine has significant activity against melanomas. It is a synthetic analog of naturally occurring purine precursor 5-amino-1H-imidazole-4-carboxamide (AIC). Dacarbazine appears to exert cytotoxic effects by acting as an alkylating agent, by inhibiting DNA synthesis as a purine analog, and by inducing apoptosis1. Dacarbazine is not cell cycle-phase specific.
Molecular Spectra
No Data Available
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References
No Data Available
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