Substance
ID:182265
Names and Identifiers
IUPAC name
(1'S,2R,2'R,9'R,10'R,11'S,15'S)-9'-(acetylsulfanyl)-2',15'-dimethylspiro[oxolane-2,14'-tetracyclo[8.7.0.02,7.011,15]heptadecan]-6'-ene-5,5'-dione
IUPAC Traditional name
spironolactone
Synonyms
4-Pregnen-21-oic acid-17α-ol-3-one-7α-thiol γ-lactone 7-acetate7α-(Acetylthio)-17α-hydroxy-3-oxopregn-4-ene-21-carboxylic acid γ-lactoneSpironolactone
Properties
Physical Property
Melting Point
207-208 °C(lit.)
Safety Information
GHS Precautionary statements
P201-P308+P313
European Hazard Symbols
Toxic (T)Safety Statements
53-22-36/37/39-45
Risk Statements
60
GHS Pictograms
Respiratory sensitization, category 1
Germ cell mutagenicity, categories 1A,1B,2
Carcinogenicity, categories 1A,1B,2
Reproductive toxicity, categories 1A,1B,2
Specific Target Organ Toxicity – Single exposure, categories 1,2
Specific Target Organ Toxicity – Repeated exposure, categories 1,2
Aspiration Hazard, category 1
GHS Hazard statements
H360
Personal Protective Equipment
Eyeshields, Gloves, type P2 (EN 143) respirator cartridges
GHS Signal Word
Danger
German water hazard class
3
Pharmacology Properties
Gene Information
human ... HSD17B1(3292), NR3C2(4306)rat ... Ar(24208)
Product Information
Purity
97.0-103.0%
Molecule Details
Biochem/physiol Actions
Spironolactone is a competitive aldosterone receptor antagonist. Used as potassium sparing diuretic.
Other Notes
Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. S3378.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.
Spironolactone is a competitive aldosterone receptor antagonist. Used as potassium sparing diuretic.
Other Notes
Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. S3378.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.
Molecular Spectra
No Data Available
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References
No Data Available
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