Substance
ID:182232
Names and Identifiers
Synonyms
MK-93322,23-Dihydroavermectin B1Ivermectin
IUPAC name
(1'R,2R,4'S,5S,6R,8'R,10'Z,12'S,13'S,14'Z,20'R,21'R,24'S)-6-[(2S)-butan-2-yl]-21',24'-dihydroxy-12'-{[(2R,4S,5S,6S)-5-{[(2S,4S,5S,6S)-5-hydroxy-4-methoxy-6-methyloxan-2-yl]oxy}-4-methoxy-6-methyloxan-2-yl]oxy}-5,11',13',22'-tetramethyl-3',7',19'-trioxaspiro[oxane-2,6'-tetracyclo[15.6.1.14,8.020,24]pentacosane]-10',14',16',22'-tetraen-2'-one
IUPAC Traditional name
(1'R,2R,4'S,5S,6R,8'R,10'Z,12'S,13'S,14'Z,20'R,21'R,24'S)-6-[(2S)-butan-2-yl]-21',24'-dihydroxy-12'-{[(2R,4S,5S,6S)-5-{[(2S,4S,5S,6S)-5-hydroxy-4-methoxy-6-methyloxan-2-yl]oxy}-4-methoxy-6-methyloxan-2-yl]oxy}-5,11',13',22'-tetramethyl-3',7',19'-trioxaspiro[oxane-2,6'-tetracyclo[15.6.1.14,8.020,24]pentacosane]-10',14',16',22'-tetraen-2'-one
Properties
Pharmacology Properties
Gene Information
human ... ABCB1(5243), CYP3A4(1576)mouse ... Abcb1a(18671), Abcb1b(18669)
Safety Information
GHS Precautionary statements
P201-P264-P301+P310-P308+P313
German water hazard class
3
GHS Hazard statements
H300-H360
Packing Group
2
Risk Statements
61-28
GHS Pictograms
Respiratory sensitization, category 1
Germ cell mutagenicity, categories 1A,1B,2
Carcinogenicity, categories 1A,1B,2
Reproductive toxicity, categories 1A,1B,2
Specific Target Organ Toxicity – Single exposure, categories 1,2
Specific Target Organ Toxicity – Repeated exposure, categories 1,2
Aspiration Hazard, category 1
Acute toxicity (oral, dermal, inhalation), categories 1,2,3
RID/ADR
UN 2811 6.1/PG 2
Storage Temperature
2-8°C
Personal Protective Equipment
Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
Safety Statements
53-28-36/37-45
Hazard Class
6.1
GHS Signal Word
Danger
UN Number
2811
European Hazard Symbols
Highly toxic (T+)Physical Property
Solubility
MEK: soluble50 mg/mL
Molecule Details
Frequently Asked Questions
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Other Notes
Primarily ivermectin B1a.
Biochem/physiol Actions
Positive allosteric modulator of α7 neuronal nicotinic acetylcholine receptor; also modulates glutamate-GABA-activated chloride channels.
Live Chat and Frequently Asked Questions are available for this Product.
Other Notes
Primarily ivermectin B1a.
Biochem/physiol Actions
Positive allosteric modulator of α7 neuronal nicotinic acetylcholine receptor; also modulates glutamate-GABA-activated chloride channels.
Molecular Spectra
No Data Available
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References
No Data Available
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