Substance
ID:182231
Names and Identifiers
IUPAC name
1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-(trifluoromethyl)-1,2,3,4-tetrahydropyrimidine-2,4-dione
IUPAC Traditional name
trifluridine
Synonyms
TrifluridineTrifluorothymine deoxyribosideTrifluorothymidineα,α,α-Trifluorothymidine2′-Deoxy-5-trifluoromethyluridine
Properties
Product Information
Purity
≥99% (HPLC)
Physical Property
Melting Point
190-193 °C(lit.)
Safety Information
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
European Hazard Symbols
Harmful (Xn)Safety Statements
22-36
GHS Pictograms
Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, category 2
Eye irritation, category 2
Skin sensitisation, category 1
Specific Target Organ Toxicity – Single exposure, category 3
Respiratory sensitization, category 1
Germ cell mutagenicity, categories 1A,1B,2
Carcinogenicity, categories 1A,1B,2
Reproductive toxicity, categories 1A,1B,2
Specific Target Organ Toxicity – Single exposure, categories 1,2
Specific Target Organ Toxicity – Repeated exposure, categories 1,2
Aspiration Hazard, category 1
RTECS
XP2087500
Storage Temperature
-20°C
German water hazard class
3
GHS Hazard statements
H302-H312-H332-H351
Risk Statements
20/21/22-40
GHS Signal Word
Warning
GHS Precautionary statements
P280
Molecule Details
Application
Trifluorothymidine (Trifluridine, TFT) is a substrate used to study the specificity and kinetics of thymidine kinase(s). TFT after phosphorylation may be incorporated into DNA where is induces DNA-damage, consequently TFT is useful for studies of DNA repair mechanisms. TFT may also be used to study mechanisms of inhibition of thymidylate synthase(s).
Trifluorothymidine (Trifluridine, TFT) is a substrate used to study the specificity and kinetics of thymidine kinase(s). TFT after phosphorylation may be incorporated into DNA where is induces DNA-damage, consequently TFT is useful for studies of DNA repair mechanisms. TFT may also be used to study mechanisms of inhibition of thymidylate synthase(s).
Molecular Spectra
No Data Available
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References
No Data Available
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