Substance
ID:182162
Names and Identifiers
Synonyms
Diazoxide7-Chloro-3-methyl-2H-1,2,4-benzothiadiazine 1,1-dioxide
IUPAC Traditional name
diazoxide
IUPAC name
7-chloro-3-methyl-2H-1λ6,2,4-benzothiadiazine-1,1-dione
Properties
Safety Information
Safety Statements
22-26-36
European Hazard Symbols
Harmful (Xn)GHS Precautionary statements
P261-P305+P351+P338
Risk Statements
22-36/37/38
GHS Hazard statements
H302-H315-H319-H335
RTECS
DK8185000
GHS Pictograms
Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, category 2
Eye irritation, category 2
Skin sensitisation, category 1
Specific Target Organ Toxicity – Single exposure, category 3
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
German water hazard class
3
GHS Signal Word
Warning
Pharmacology Properties
Gene Information
human ... KCNA1(3736), KCNJ11(3767), KCNMA1(3778)mouse ... Kcnj1(56379), Kcnj11(16514)rat ... Gria1(50592), Kcna1(24520), Kcnj1(24521), Kcnj11(83535), Kcnj8(25472)
Physical Property
Solubility
methanol: soluble
H2O: insoluble
0.1 M NaOH: soluble
Molecule Details
Biochem/physiol Actions
Selective ATP-sensitive K+ channel activator in both vascular smooth muscle and pancreatic β-cells; antihypertensive.
Selective ATP-sensitive K+ channel activator in both vascular smooth muscle and pancreatic β-cells; antihypertensive.
Molecular Spectra
No Data Available
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References
No Data Available
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