Substance
ID:182078
Names and Identifiers
IUPAC name
2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetic acid
Synonyms
1-(4-氯苯甲酰基)-5-甲氧基-2-甲基-3-吲哚乙酸Indomethacin吲哚美辛
IUPAC Traditional name
indomethacin
Registration numbers
CAS Number
MDL Number
EC Number
Beilstein Number
PubChem SID
Properties
Safety Information
GHS Hazard statements
H300
Safety Statements
28-36/37-45
Hazard Class
6.1
Packing Group
1
UN Number
2811
GHS Precautionary statements
P264-P301+P310
German water hazard class
3
Personal Protective Equipment
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
RTECS
NL3500000
RID/ADR
UN 2811 6.1/PG 1
GHS Pictograms
Acute toxicity (oral, dermal, inhalation), categories 1,2,3
GHS Signal Word
Danger
European Hazard Symbols
Highly toxic (T+)Risk Statements
28
Pharmacology Properties
Gene Information
human ... ALB(213), ALOX5(240), ELA2(1991), GPR44(11251), IL1A(3552), PLA2G1B(5319), PTGDR(5729), PTGS1(5742), PTGS2(5743)mouse ... Alox5(11689), Ptgdr(19214), Ptger1(19216), Ptger2(19217), Ptger3(19218), Ptger4(19219), Ptgs1(19224), Ptgs2(19225)rat ... Alox5(25290), Ptgs1(24693), Ptgs2(29527)
Product Information
Suitability
meets USP testing specifications
Molecule Details
Biochem/physiol Actions
Used as a non-selective inhibitor of cyclooxygenases, COX1 and COX2, leading to reduced prostaglandin biosynthesis from arachidonic acid.
环加氧酶 (COX) 抑制剂，对 COX-1 的选择性相对较高。
Used as a non-selective inhibitor of cyclooxygenases, COX1 and COX2, leading to reduced prostaglandin biosynthesis from arachidonic acid.
环加氧酶 (COX) 抑制剂，对 COX-1 的选择性相对较高。
Molecular Spectra
No Data Available
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References
No Data Available
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