Application
Phosphomycin, also known as Fosfomycin, is an antibiotic produced by Streptomyces fradiae. It is used to treat uncomplicated urinary tract infections and to reduce nephrotoxicity and ototoxicity of platinum-containing anti-tumor agents. It is used for susceptibility studies of Klebsiella pneumoniae1 and to study in vitro susceptibility testing procedures for fosfomycin tromethamine2.
Biochem/physiol Actions
Fosfomycin is a phosphoenolpyruvate analog. It irreversibly inhibits enolpyruvate transferase (MurA). Therefore, the producion of N-acetylmuramic acid, an essential element of the peptidoglycan cell wall is inhibited.
聚集在肾脏和膀胱中的抗生素；降低含铂抗肿瘤制剂的肾毒性和耳毒性。磷霉素可以抑制 UDP-GlcNAc 烯醇式丙酮酸转移酶 (MurA)（细菌细胞壁生物合成中的酶）。