Substance
ID:181929
Names and Identifiers
IUPAC Traditional name
cyclophosphamide hydrate
Synonyms
Cytoxan环磷酰胺 一水合物2-[双(2-氯乙基)氨基]四氢-2H-1,3,2-噁磷-2-氧化物Cyclophosphamide monohydrate
IUPAC name
2-[bis(2-chloroethyl)amino]-1,3,2λ5-oxazaphosphinan-2-one hydrate
Registration numbers
CAS Number
Beilstein Number
MDL Number
EC Number
PubChem SID
Properties
Safety Information
GHS Precautionary statements
P201-P301+P310-P308+P313
Hazard Class
6.1
European Hazard Symbols
Toxic (T)Packing Group
3
GHS Pictograms
Respiratory sensitization, category 1
Germ cell mutagenicity, categories 1A,1B,2
Carcinogenicity, categories 1A,1B,2
Reproductive toxicity, categories 1A,1B,2
Specific Target Organ Toxicity – Single exposure, categories 1,2
Specific Target Organ Toxicity – Repeated exposure, categories 1,2
Aspiration Hazard, category 1
Acute toxicity (oral, dermal, inhalation), categories 1,2,3
German water hazard class
3
GHS Signal Word
Danger
Personal Protective Equipment
Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
UN Number
3464
RTECS
RP6157750
GHS Hazard statements
H301-H350
RID/ADR
UN 3464 6.1/PG 3
Safety Statements
53-45
Risk Statements
45-25
Storage Temperature
2-8°C
Physical Property
Solubility
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Flash Point
113 °C
235.4 °F
Melting Point
49-51 °C(lit.)
Molecule Details
Application
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Caution
Injecting a compatible solvent directly into the vial permits preparation of any desired strength solution without exposure.
包装
Packaged in a 100 mL serum bottle with butyl rubber stopper and aluminum tear seal.
Reconstitution
Dissolving the contents in 100 mL of solvent yields a 1% solution.
Biochem/physiol Actions
环磷酰胺是一种广泛用于癌症化疗的具有细胞毒性的氮芥衍生物。它可与 DNA 交联、导致链断裂并诱导突变。其临床活性与乙醛脱氢酶 1 (ALDH1) 的活性降低相关。
法律信息
Isopac is a registered trademark of Sigma-Aldrich Co. LLC
Do you have application information on this product that you would like to share?
Caution
Injecting a compatible solvent directly into the vial permits preparation of any desired strength solution without exposure.
包装
Packaged in a 100 mL serum bottle with butyl rubber stopper and aluminum tear seal.
Reconstitution
Dissolving the contents in 100 mL of solvent yields a 1% solution.
Biochem/physiol Actions
环磷酰胺是一种广泛用于癌症化疗的具有细胞毒性的氮芥衍生物。它可与 DNA 交联、导致链断裂并诱导突变。其临床活性与乙醛脱氢酶 1 (ALDH1) 的活性降低相关。
法律信息
Isopac is a registered trademark of Sigma-Aldrich Co. LLC
Molecular Spectra
No Data Available
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References
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