Substance
ID:181928
Names and Identifiers
IUPAC Traditional name
cyclophosphamide hydrate
Synonyms
Cytoxan环磷酰胺 一水合物2-[双(2-氯乙基)氨基]四氢-2H-1,3,2-噁磷-2-氧化物Cyclophosphamide monohydrate
IUPAC name
2-[bis(2-chloroethyl)amino]-1,3,2λ5-oxazaphosphinan-2-one hydrate
Registration numbers
CAS Number
Beilstein Number
PubChem SID
MDL Number
EC Number
Properties
Pharmacology Properties
Gene Information
human ... ALDH1A1(216), ALDH1B1(219)
Physical Property
Flash Point
235.4 °F
113 °C
Melting Point
49-51 °C(lit.)
Safety Information
Hazard Class
6.1
Packing Group
3
RID/ADR
UN 3464 6.1/PG 3
GHS Pictograms
Respiratory sensitization, category 1
Germ cell mutagenicity, categories 1A,1B,2
Carcinogenicity, categories 1A,1B,2
Reproductive toxicity, categories 1A,1B,2
Specific Target Organ Toxicity – Single exposure, categories 1,2
Specific Target Organ Toxicity – Repeated exposure, categories 1,2
Aspiration Hazard, category 1
Acute toxicity (oral, dermal, inhalation), categories 1,2,3
Storage Temperature
2-8°C
UN Number
3464
GHS Signal Word
Danger
GHS Hazard statements
H301-H350
GHS Precautionary statements
P201-P301+P310-P308+P313
RTECS
RP6157750
European Hazard Symbols
Toxic (T)Risk Statements
45-25
German water hazard class
3
Safety Statements
53-45
Personal Protective Equipment
Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
Product Information
Purity
97.0-103.0% (HPLC)
Molecule Details
包装
1, 5, 10, 25 g in glass bottle
Biochem/physiol Actions
环磷酰胺是一种广泛用于癌症化疗的具有细胞毒性的氮芥衍生物。它可与 DNA 交联、导致链断裂并诱导突变。其临床活性与乙醛脱氢酶 1 (ALDH1) 的活性降低相关。
1, 5, 10, 25 g in glass bottle
Biochem/physiol Actions
环磷酰胺是一种广泛用于癌症化疗的具有细胞毒性的氮芥衍生物。它可与 DNA 交联、导致链断裂并诱导突变。其临床活性与乙醛脱氢酶 1 (ALDH1) 的活性降低相关。
Molecular Spectra
No Data Available
Click here to submit data
References
No Data Available
Click here to submit data