Substance
ID:181888
Names and Identifiers
IUPAC Traditional name
cytarabine
Synonyms
Ara-C胞嘧啶 β-D-呋喃阿拉伯糖苷阿糖胞苷Cytosine β-D-arabinofuranoside胞嘧啶阿拉伯糖苷阿糖胞嘧啶(β-D-阿拉伯呋喃糖基)胞嘧啶阿拉伯糖胞嘧啶
IUPAC name
4-amino-1-[(2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2-dihydropyrimidin-2-one
Registration numbers
CAS Number
PubChem SID
Beilstein Number
EC Number
MDL Number
Properties
Safety Information
GHS Pictograms
Respiratory sensitization, category 1
Germ cell mutagenicity, categories 1A,1B,2
Carcinogenicity, categories 1A,1B,2
Reproductive toxicity, categories 1A,1B,2
Specific Target Organ Toxicity – Single exposure, categories 1,2
Specific Target Organ Toxicity – Repeated exposure, categories 1,2
Aspiration Hazard, category 1
Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, category 2
Eye irritation, category 2
Skin sensitisation, category 1
Specific Target Organ Toxicity – Single exposure, category 3
Personal Protective Equipment
Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
European Hazard Symbols
Harmful (Xn)Safety Statements
36/37
GHS Signal Word
Warning
Storage Temperature
2-8°C
GHS Hazard statements
H317-H361
RTECS
HA5425000
German water hazard class
3
GHS Precautionary statements
P280
Risk Statements
63-43
Physical Property
Apperance
crystalline
Product Information
Purity
≥90% (HPLC)
Pharmacology Properties
Gene Information
human ... POLB(5423)mouse ... Cda(72269)
Molecule Details
Biochem/physiol Actions
阿糖胞苷复合到 DNA 中后，可通过与导致 DNA 断裂的拓扑异构酶 I 形成可裂解复合物而抑制 DNA 的复制，但不会抑制 RNA 的合成。抗白血病制剂。
阿糖胞苷复合到 DNA 中后，可通过与导致 DNA 断裂的拓扑异构酶 I 形成可裂解复合物而抑制 DNA 的复制，但不会抑制 RNA 的合成。抗白血病制剂。
Molecular Spectra
No Data Available
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References
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