Substance
ID:181755
Names and Identifiers
Synonyms
Ac-DEVD-AFCN-Acetyl-Asp-Glu-Val-Asp-7-amido-4-trifluoromethylcoumarin
IUPAC name
(4S)-4-{[(1S)-1-{[(1S)-2-carboxy-1-{[2-oxo-4-(trifluoromethyl)-2H-chromen-7-yl]carbamoyl}ethyl]carbamoyl}-2-methylpropyl]carbamoyl}-4-[(2S)-3-carboxy-2-acetamidopropanamido]butanoic acid
IUPAC Traditional name
(4S)-4-{[(1S)-1-{[(1S)-2-carboxy-1-{[2-oxo-4-(trifluoromethyl)chromen-7-yl]carbamoyl}ethyl]carbamoyl}-2-methylpropyl]carbamoyl}-4-[(2S)-3-carboxy-2-acetamidopropanamido]butanoic acid
Properties
Physical Property
Solubility
H2O: soluble1 mg/mL
Apperance
white powder
Safety Information
Personal Protective Equipment
Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Storage Temperature
-20°C
German water hazard class
3
Product Information
Purity
≥90% (HPLC)
Pharmacology Properties
Gene Information
human ... CASP3(836)
Molecule Details
Amino Acid Sequence
NAc-Asp-Glu-Val-Asp-AFC
Biochem/physiol Actions
A fluorogenic substrate for caspase 3, a protease that is rapidly activated when cells are exposed to apoptotic conditions and that cleaves poly(ADP-ribose) polymerase. The 7-amido-4-trifluoromethylcoumarin derivative has better membrane permeability than the 7-amido-4-methylcoumarin derivative (A1086).
NAc-Asp-Glu-Val-Asp-AFC
Biochem/physiol Actions
A fluorogenic substrate for caspase 3, a protease that is rapidly activated when cells are exposed to apoptotic conditions and that cleaves poly(ADP-ribose) polymerase. The 7-amido-4-trifluoromethylcoumarin derivative has better membrane permeability than the 7-amido-4-methylcoumarin derivative (A1086).
Molecular Spectra
No Data Available
Click here to submit data
References
No Data Available
Click here to submit data