Substance
ID:181518
Names and Identifiers
IUPAC name
6-chloro-10-(piperazin-1-yl)-2,9-diazatricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,9,11,13-heptaene
IUPAC Traditional name
NDMC
Synonyms
NormethylclozapineN-DesmethylclozapineNorclozapine8-Chloro-11-piperazinyl-5H-dibenzo[b,e][1,4]diazepine
Properties
Safety Information
Risk Statements
20/22-36/37/38
GHS Pictograms
Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, category 2
Eye irritation, category 2
Skin sensitisation, category 1
Specific Target Organ Toxicity – Single exposure, category 3
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
European Hazard Symbols
Harmful (Xn)GHS Signal Word
Warning
GHS Precautionary statements
P261-P305+P351+P338
Safety Statements
22-36-45
German water hazard class
3
GHS Hazard statements
H302-H315-H319-H332-H335
Pharmacology Properties
Gene Information
human ... KCNH1(3756)
Molecule Details
Biochem/physiol Actions
Major metabolite of clozapine; potent 5-HT2 serotonin receptor antagonist and a ligand for the cloned 5-HT6 and 5-HT7 serotonin receptors. Also an allosteric potentiator of M1 muscarinic receptors.
Major metabolite of clozapine; potent 5-HT2 serotonin receptor antagonist and a ligand for the cloned 5-HT6 and 5-HT7 serotonin receptors. Also an allosteric potentiator of M1 muscarinic receptors.
Molecular Spectra
No Data Available
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References
No Data Available
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