Substance
ID:181444
Names and Identifiers
IUPAC Traditional name
3-{2-[2-(2-{2-[2-(2-{2-[2-(2-{2-[2-(2-amino-3-hydroxypropanamido)-4-methylpentanamido]-5-carbamimidamidopentanamido}-5-carbamimidamidopentanamido)-3-hydroxypropanamido]-3-hydroxypropanamido}-3-sulfanylpropanamido)-3-phenylpropanamido]acetamido}acetamido)-5-carbamimidamidopentanamido]-4-(methylsulfanyl)butanamido}-3-({4-carbamimidamido-1-[(1-{[({1-[(1-{[1-({[(1-{[({1-[(1-{[1-({1-[(4-carbamimidamido-1-{[1-carboxy-2-(4-hydroxyphenyl)ethyl]carbamoyl}butyl)carbamoyl]-2-phenylethyl}carbamoyl)-2-hydroxyethyl]carbamoyl}-2-carbamoylethyl)carbamoyl]-2-sulfanylethyl}carbamoyl)methyl]carbamoyl}-3-methylbutyl)carbamoyl]methyl}carbamoyl)-2-hydroxyethyl]carbamoyl}-3-carbamoylpropyl)carbamoyl]ethyl}carbamoyl)methyl]carbamoyl}-2-methylbutyl)carbamoyl]butyl}carbamoyl)propanoic acid
IUPAC name
3-{2-[2-(2-{2-[2-(2-{2-[2-(2-{2-[2-(2-amino-3-hydroxypropanamido)-4-methylpentanamido]-5-carbamimidamidopentanamido}-5-carbamimidamidopentanamido)-3-hydroxypropanamido]-3-hydroxypropanamido}-3-sulfanylpropanamido)-3-phenylpropanamido]acetamido}acetamido)-5-carbamimidamidopentanamido]-4-(methylsulfanyl)butanamido}-3-({4-carbamimidamido-1-[(1-{[({1-[(1-{[1-({[(1-{[({1-[(1-{[1-({1-[(4-carbamimidamido-1-{[1-carboxy-2-(4-hydroxyphenyl)ethyl]carbamoyl}butyl)carbamoyl]-2-phenylethyl}carbamoyl)-2-hydroxyethyl]carbamoyl}-2-carbamoylethyl)carbamoyl]-2-sulfanylethyl}carbamoyl)methyl]carbamoyl}-3-methylbutyl)carbamoyl]methyl}carbamoyl)-2-hydroxyethyl]carbamoyl}-3-carbamoylpropyl)carbamoyl]ethyl}carbamoyl)methyl]carbamoyl}-2-methylbutyl)carbamoyl]butyl}carbamoyl)propanoic acid
Synonyms
Atrial Natriuretic Peptide humanANF 1-28hANF
Properties
Safety Information
Personal Protective Equipment
Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Storage Temperature
-20°C
German water hazard class
3
Product Information
Purity
≥97% (HPLC)
Pharmacology Properties
Gene Information
human ... NPPA(4878)
Molecule Details
Amino Acid Sequence
Ser-Leu-Arg-Arg-Ser-Ser-Cys-Phe-Gly-Gly-Arg-Met-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-Tyr [Disulfide bridge: 7-23]
Biochem/physiol Actions
Atrial natriuretic peptide (ANP) is synthesized in myoendocrine cells of the heart from which it is released into the circulation. It exerts natriuretic, diuretic, and vasodilatory effects through stimulation of guanylate cyclase-linked NPR-A receptors. It plays an important role in blood volume and blood pressure homeostasis.
Ser-Leu-Arg-Arg-Ser-Ser-Cys-Phe-Gly-Gly-Arg-Met-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-Tyr [Disulfide bridge: 7-23]
Biochem/physiol Actions
Atrial natriuretic peptide (ANP) is synthesized in myoendocrine cells of the heart from which it is released into the circulation. It exerts natriuretic, diuretic, and vasodilatory effects through stimulation of guanylate cyclase-linked NPR-A receptors. It plays an important role in blood volume and blood pressure homeostasis.
Molecular Spectra
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References
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