Substance
ID:181410
Names and Identifiers
IUPAC name
P-methyl-1,2,3,6-tetrahydropyridin-1-ium-4-phosphinate hydrate
IUPAC Traditional name
P-methyl-1,2,3,6-tetrahydropyridin-1-ium-4-phosphinate hydrate
Synonyms
TPMPA hydrate(1,2,5,6-Tetrahydropyridin-4-yl)methylphosphinic acid hydrate
Properties
Product Information
Purity
≥97% (NMR)
Physical Property
Solubility
H2O: soluble16 mg/mL
DMSO: insoluble
Apperance
white to off-white solid
Safety Information
German water hazard class
3
Personal Protective Equipment
Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Molecule Details
Legal Information
Sold in the USA under exclusive license from the University of California.
Biochem/physiol Actions
TPMPA is a hybrid of isoguvacine and 3-APMPA designed to retain affinity for GABAC receptors but not to interact with GABAA or GABAB receptors. Electrical assays show that TPMPA is a competitive antagonist of cloned human mu 1 GABAC receptors expressed in Xenopus laevis oocytes (Kb approx. 2 μM). TPMPA is >100-fold weaker as an inhibitor of rat brain GABAA receptors expressed in oocytes (Kb approx. 320 μM) and has only weak agonist activity on GABAB receptors assayed in rat hippocampal slices (EC50 approx. 500 μM). TPMPA may be used to investigate GABAC receptor function in the outer retina and in any other areas of the nervous system in which these types of receptor are present.
Sold in the USA under exclusive license from the University of California.
Biochem/physiol Actions
TPMPA is a hybrid of isoguvacine and 3-APMPA designed to retain affinity for GABAC receptors but not to interact with GABAA or GABAB receptors. Electrical assays show that TPMPA is a competitive antagonist of cloned human mu 1 GABAC receptors expressed in Xenopus laevis oocytes (Kb approx. 2 μM). TPMPA is >100-fold weaker as an inhibitor of rat brain GABAA receptors expressed in oocytes (Kb approx. 320 μM) and has only weak agonist activity on GABAB receptors assayed in rat hippocampal slices (EC50 approx. 500 μM). TPMPA may be used to investigate GABAC receptor function in the outer retina and in any other areas of the nervous system in which these types of receptor are present.
Molecular Spectra
No Data Available
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References
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