Substance

ID:181396

Names and Identifiers
IUPAC Traditional name
sulindac
Synonyms
(Z)-5-氟-2-甲基-1-[4-(甲亚硫酰苯基)亚甲基]-1H-茚-3-醋酸Sulindac舒林酸
IUPAC name
2-[(1Z)-5-fluoro-1-[(4-methanesulfinylphenyl)methylidene]-2-methyl-1H-inden-3-yl]acetic acid
Registration numbers
CAS Number
38194-50-2
MDL Number
MFCD00599589
EC Number
253-819-2
PubChem SID
24277737
Properties
Safety Information
RTECS
NK8226000
Packing Group
3
RID/ADR
UN 2811 6.1/PG 3
GHS Pictograms
GHS08
Respiratory sensitization, category 1
Germ cell mutagenicity, categories 1A,1B,2
Carcinogenicity, categories 1A,1B,2
Reproductive toxicity, categories 1A,1B,2
Specific Target Organ Toxicity – Single exposure, categories 1,2
Specific Target Organ Toxicity – Repeated exposure, categories 1,2
Aspiration Hazard, category 1
GHS06
Acute toxicity (oral, dermal, inhalation), categories 1,2,3
GHS Hazard statements
H301-H317-H334-H361
Hazard Class
6.1
GHS Precautionary statements
P261-P280-P301+P310-P342+P311
European Hazard Symbols
Harmful Harmful (Xn)
Personal Protective Equipment
Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
Risk Statements
63-22-42/43
UN Number
2811
German water hazard class
3
GHS Signal Word
Danger
Product Information
Purity
≥98.0%
Pharmacology Properties
Gene Information
human ... ALB(213), PTGS2(5743)
Molecule Details
Biochem/physiol Actions
非甾体抗炎药；COX-1 的选择性抑制剂。
Application
Treatment of human colorectal cancer cell lines induces MRP1 and MRP3 but not other members of the MRP family. Reported to significantly increase the cytotoxicity of the anthracyclines (doxorubicin, daunorubicin and epirubicin), as well as teniposide, VP-16 and vincristine.
Molecular Spectra
No Data Available
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References
No Data Available
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