Substance
ID:181255
Names and Identifiers
IUPAC name
(4S)-4-{[(1S)-3-carbamoyl-1-{[(2R)-1-hydroxy-3-phenylpropan-2-yl]carbamoyl}propyl]carbamoyl}-4-(2-{2-[(2S)-2-{[(2S)-1-{2-[(2S)-2-(2-{2-[(2S)-2-{2-[(2S)-4-carbamoyl-2-[(2S)-2-{2-[(2S)-2-(2-{[(2S)-1-(2-acetamido-2-methylpropanoyl)pyrrolidin-2-yl]formamido}-2-methylpropanamido)propanamido]-2-methylpropanamido}propanamido]butanamido]-2-methylpropanamido}-3-methylbutanamido]-2-methylpropanamido}acetamido)-4-methylpentanamido]-2-methylpropanoyl}pyrrolidin-2-yl]formamido}-3-methylbutanamido]-2-methylpropanamido}-2-methylpropanamido)butanoic acid
IUPAC Traditional name
(4S)-4-{[(1S)-3-carbamoyl-1-{[(2R)-1-hydroxy-3-phenylpropan-2-yl]carbamoyl}propyl]carbamoyl}-4-(2-{2-[(2S)-2-{[(2S)-1-{2-[(2S)-2-(2-{2-[(2S)-2-{2-[(2S)-4-carbamoyl-2-[(2S)-2-{2-[(2S)-2-(2-{[(2S)-1-(2-acetamido-2-methylpropanoyl)pyrrolidin-2-yl]formamido}-2-methylpropanamido)propanamido]-2-methylpropanamido}propanamido]butanamido]-2-methylpropanamido}-3-methylbutanamido]-2-methylpropanamido}acetamido)-4-methylpentanamido]-2-methylpropanoyl}pyrrolidin-2-yl]formamido}-3-methylbutanamido]-2-methylpropanamido}-2-methylpropanamido)butanoic acid
Synonyms
Antibiotic U-22324Alamethicin from Trichoderma viride
Registration numbers
Beilstein Number
CAS Number
PubChem SID
MDL Number
Properties
Product Information
Quality Level
PREMIUM
Purity
≥98% (HPLC)
Safety Information
Safety Statements
45
GHS Precautionary statements
P301+P310
RID/ADR
UN 3462 6.1/PG 3
GHS Signal Word
Danger
GHS Hazard statements
H301
Storage Temperature
2-8°C
Risk Statements
25
UN Number
3462
GHS Pictograms
Acute toxicity (oral, dermal, inhalation), categories 1,2,3
Packing Group
3
European Hazard Symbols
Toxic (T)Personal Protective Equipment
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Hazard Class
6.1
German water hazard class
3
Molecule Details
Antibody Adsorbant
Ac-2-MeAla-L-Pro-2-MeAla-L-Ala-2-MeAla-L-Ala-L-Glu(NH2)-2-MeAla-L-Val-2-MeAla-Gly-L-Leu-2-MeAla-L-Pro-L-Val-2-MeAla-2-MeAla-L-Glu-L-Glu(NH2)-phenylalaninol
Biochem/physiol Actions
Monovalent cation ionophore; can mimic nerve action potential across artificial membranes.
Quality
A mixture of alamethicin homologs
Application
Alamethicin is a monovalent cation ionophore which can mimic nerve action potential across artificial membranes. Alamethicin has also been used to study membrane interactions of antimicrobial peptides.
Ac-2-MeAla-L-Pro-2-MeAla-L-Ala-2-MeAla-L-Ala-L-Glu(NH2)-2-MeAla-L-Val-2-MeAla-Gly-L-Leu-2-MeAla-L-Pro-L-Val-2-MeAla-2-MeAla-L-Glu-L-Glu(NH2)-phenylalaninol
Biochem/physiol Actions
Monovalent cation ionophore; can mimic nerve action potential across artificial membranes.
Quality
A mixture of alamethicin homologs
Application
Alamethicin is a monovalent cation ionophore which can mimic nerve action potential across artificial membranes. Alamethicin has also been used to study membrane interactions of antimicrobial peptides.
Molecular Spectra
No Data Available
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References
No Data Available
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