Substance
ID:180869
Names and Identifiers
IUPAC Traditional name
(4R,6R,8R,9Z,11Z)-16-chloro-17,19-dihydroxy-4-methyl-3,7-dioxatricyclo[13.4.0.06,8]nonadeca-1(15),9,11,16,18-pentaene-2,13-dione
IUPAC name
(4R,6R,8R,9Z,11Z)-16-chloro-17,19-dihydroxy-4-methyl-3,7-dioxatricyclo[13.4.0.06,8]nonadeca-1(15),9,11,16,18-pentaene-2,13-dione
Synonyms
[1aS-(1aR*,2Z,4E,14*,15aR*)]-8-Chloro-1a,14,15,15a-tetrahydro-9,11-dihydroxy-14-methyl-6H-oxireno[e][2]benzoxacyclotetradecin-6,12(7H)-dioneMonordenRadicicol from Diheterospora chlamydosporia
Properties
Safety Information
Risk Statements
45-46-22-36/37/38
GHS Pictograms
Acute toxicity (oral, dermal, inhalation), categories 1,2,3
Respiratory sensitization, category 1
Germ cell mutagenicity, categories 1A,1B,2
Carcinogenicity, categories 1A,1B,2
Reproductive toxicity, categories 1A,1B,2
Specific Target Organ Toxicity – Single exposure, categories 1,2
Specific Target Organ Toxicity – Repeated exposure, categories 1,2
Aspiration Hazard, category 1
Packing Group
3
German water hazard class
3
Hazard Class
6.1
GHS Hazard statements
H301-H315-H319-H335-H340-H350
GHS Signal Word
Danger
RID/ADR
UN 2811 6.1/PG 3
Storage Temperature
-20°C
European Hazard Symbols
Toxic (T)GHS Precautionary statements
P201-P261-P301+P310-P305+P351+P338-P308+P313
Safety Statements
53-26-45
UN Number
2811
Physical Property
Solubility
ethanol: soluble10 mg/mL
Apperance
yellow solid
Pharmacology Properties
Gene Information
human ... HSP90AA1(3320), SRC(6714)rat ... Src(83805)
Molecule Details
Biochem/physiol Actions
Antifungal macrolactone antibiotic that inhibits protein tyrosine kinase. Radicicol induces the differentiation of HL-60 cells into macrophages, blocking cell cycle at G1 and G2. It suppresses NIH 3T3 cell transformation by diverse oncogenes such as src, ras and mos and also suppresses the expression of mitogen-inducible cyclooxygenase-2. As a cell differentiation modulator, radicicol has anti-angiogenic activity in vivo, inhibiting the proliferation of and plasminogen activator production by vascular endothelial cells.
Caution
Photosensitive
Antifungal macrolactone antibiotic that inhibits protein tyrosine kinase. Radicicol induces the differentiation of HL-60 cells into macrophages, blocking cell cycle at G1 and G2. It suppresses NIH 3T3 cell transformation by diverse oncogenes such as src, ras and mos and also suppresses the expression of mitogen-inducible cyclooxygenase-2. As a cell differentiation modulator, radicicol has anti-angiogenic activity in vivo, inhibiting the proliferation of and plasminogen activator production by vascular endothelial cells.
Caution
Photosensitive
Molecular Spectra
No Data Available
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References
No Data Available
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