Substance
ID:180838
Names and Identifiers
IUPAC name
(4S,4aS,5aS,6S,12aS)-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide
Synonyms
四环素Tetracycline
IUPAC Traditional name
tetracycline
Registration numbers
EC Number
MDL Number
CAS Number
Beilstein Number
PubChem SID
Properties
Safety Information
European Hazard Symbols
Harmful (Xn)Storage Temperature
-20°C
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
RTECS
QI8750000
GHS Pictograms
Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, category 2
Eye irritation, category 2
Skin sensitisation, category 1
Specific Target Organ Toxicity – Single exposure, category 3
Safety Statements
22-36
GHS Signal Word
Warning
GHS Hazard statements
H302
Risk Statements
22
German water hazard class
3
Product Information
Purity
≥88.0% (HPLC)
Pharmacology Properties
Gene Information
human ... CYP1A2(1544), TERT(7015)
Molecule Details
Application
Tetracycline is a broad spectrum polyketide antibiotic. It is used clinically to treat bacterial infections such as Rocky Mountain spotted fever, typhus fever, tick fevers, Q fever, and Brill-Zinsser disease. It is used to treat upper respiratory infections and acne1. It is used to study multidrug resistance2 as well as potential side effects such as acute pancreatitis3.
Biochem/physiol Actions
Tetracycline inhibits bacterial protein synthesis elongation at the level of aminoacyl-tRNA binding to the 30S ribosome. Tetracycline passively diffuses through porin channels in the bacterial cell membrane. It also binds to the bacterial 50S ribosomal subunit which may alter the cytoplasmic membrane, causing intracellular components to leak from bacterial cells1. Mode of resistance is via loss of cell wall permeability.
Tetracycline is a broad spectrum polyketide antibiotic. It is used clinically to treat bacterial infections such as Rocky Mountain spotted fever, typhus fever, tick fevers, Q fever, and Brill-Zinsser disease. It is used to treat upper respiratory infections and acne1. It is used to study multidrug resistance2 as well as potential side effects such as acute pancreatitis3.
Biochem/physiol Actions
Tetracycline inhibits bacterial protein synthesis elongation at the level of aminoacyl-tRNA binding to the 30S ribosome. Tetracycline passively diffuses through porin channels in the bacterial cell membrane. It also binds to the bacterial 50S ribosomal subunit which may alter the cytoplasmic membrane, causing intracellular components to leak from bacterial cells1. Mode of resistance is via loss of cell wall permeability.
Molecular Spectra
No Data Available
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References
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