Substance
ID:180820
Names and Identifiers
Synonyms
R599493-[2-[4-(bis(4-Fluorophenyl)methylene)-1-piperidinyl]ethyl]-2,3-dihydro-2-thioxo-4(1H)-quinazolinoneDiacylglycerol Kinase Inhibitor II
IUPAC Traditional name
3-(2-{4-[bis(4-fluorophenyl)methylidene]piperidin-1-yl}ethyl)-2-sulfanylidene-1H-quinazolin-4-one
IUPAC name
3-(2-{4-[bis(4-fluorophenyl)methylidene]piperidin-1-yl}ethyl)-2-sulfanylidene-1,2,3,4-tetrahydroquinazolin-4-one
Properties
Safety Information
GHS Signal Word
Warning
GHS Precautionary statements
P261-P305+P351+P338
Risk Statements
36/37/38
GHS Hazard statements
H315-H319-H335
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Storage Temperature
-20°C
European Hazard Symbols
Irritant (Xi)Safety Statements
26-36
German water hazard class
3
GHS Pictograms
Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, category 2
Eye irritation, category 2
Skin sensitisation, category 1
Specific Target Organ Toxicity – Single exposure, category 3
Physical Property
Solubility
0.1 M NaOH: slightly soluble
DMSO: soluble
ethanol: soluble
H2O: insoluble
ethyl acetate: soluble
0.1 M HCl: slightly soluble
Apperance
pale yellow solid
Molecule Details
Biochem/physiol Actions
Diacylglycerol kinase inhibitor. Inhibits formation of [38P]1-Oleoyl-2-acetylglyceryl-3-phosphoric acid (OAPA) in red blood cell membranes: IC50 = 3.3 μM.
Diacylglycerol kinase inhibitor. Inhibits formation of [38P]1-Oleoyl-2-acetylglyceryl-3-phosphoric acid (OAPA) in red blood cell membranes: IC50 = 3.3 μM.
Molecular Spectra
No Data Available
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References
No Data Available
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