Substance
ID:180746
Names and Identifiers
IUPAC Traditional name
decitabine
IUPAC name
4-amino-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2-dihydro-1,3,5-triazin-2-one
Synonyms
decitabine4-Amino-1-(2-deoxy-β-D-ribofuranosyl)-1,3,5-triazin-2(1H)-one2′-Deoxy-5-azacytidine5-Aza-2′-deoxycytidine
Registration numbers
CAS Number
EC Number
MDL Number
Beilstein Number
PubChem SID
Properties
Safety Information
GHS Pictograms
Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, category 2
Eye irritation, category 2
Skin sensitisation, category 1
Specific Target Organ Toxicity – Single exposure, category 3
Respiratory sensitization, category 1
Germ cell mutagenicity, categories 1A,1B,2
Carcinogenicity, categories 1A,1B,2
Reproductive toxicity, categories 1A,1B,2
Specific Target Organ Toxicity – Single exposure, categories 1,2
Specific Target Organ Toxicity – Repeated exposure, categories 1,2
Aspiration Hazard, category 1
GHS Signal Word
Danger
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
GHS Hazard statements
H302-H315-H319-H335-H341-H360
Risk Statements
61-22-36/37/38-68
RTECS
XZ3012000
European Hazard Symbols
Toxic (T)GHS Precautionary statements
P201-P261-P281-P305+P351+P338-P308+P313
German water hazard class
3
Safety Statements
26-36/37
Product Information
Purity
≥97%
Physical Property
Solubility
acetic acid: water (1:1): soluble50 mg/mL
Molecule Details
Frequently Asked Questions
Live Chat and Frequently Asked Questions are available for this Product.
General description
Decitabine is an epigenetic modifier that inhibits DNA methyltransferase activity which results in DNA demethylation (hypomethylation) and gene activation by remodeling "opening" chromatin. Genes are synergistically reactivated when demethylation is combined with histone hyperacetylation.
Biochem/physiol Actions
5′-Azadeoxycytidine causes DNA demethylation or hemi-demethylation. DNA demethylation can regulate gene expression by "opening" the chromatin structure detectable as increased nuclease sensitivity. This remodeling of chromatin structure allows transcription factors to bind to the promoter regions, assembly of the transcription complex, and gene expression.
Live Chat and Frequently Asked Questions are available for this Product.
General description
Decitabine is an epigenetic modifier that inhibits DNA methyltransferase activity which results in DNA demethylation (hypomethylation) and gene activation by remodeling "opening" chromatin. Genes are synergistically reactivated when demethylation is combined with histone hyperacetylation.
Biochem/physiol Actions
5′-Azadeoxycytidine causes DNA demethylation or hemi-demethylation. DNA demethylation can regulate gene expression by "opening" the chromatin structure detectable as increased nuclease sensitivity. This remodeling of chromatin structure allows transcription factors to bind to the promoter regions, assembly of the transcription complex, and gene expression.
Molecular Spectra
No Data Available
Click here to submit data
References
No Data Available
Click here to submit data