Substance
ID:180742
Names and Identifiers
IUPAC Traditional name
chamomile
IUPAC name
5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one
Synonyms
4′,5,7-TrihydroxyflavoneApigenin
Registration numbers
EC Number
MDL Number
CAS Number
Beilstein Number
PubChem SID
Properties
Safety Information
GHS Pictograms
Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, category 2
Eye irritation, category 2
Skin sensitisation, category 1
Specific Target Organ Toxicity – Single exposure, category 3
Risk Statements
36/37/38
GHS Precautionary statements
P261-P305+P351+P338
RTECS
LK9276000
GHS Signal Word
Warning
Storage Temperature
-20°C
Safety Statements
26-36
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
German water hazard class
3
GHS Hazard statements
H315-H319-H335
European Hazard Symbols
Irritant (Xi)Pharmacology Properties
Gene Information
human ... ADORA3(140), CDC2(983), CDK5(1020), CDK6(1021), CYP1A2(1544), ESR1(2099), ESR2(2100), GSK3A(2931)mouse ... Hexa(15211)rat ... Adora1(29290), Adora2a(25369), Il4(287287), Tnf(24835)
Product Information
Purity
≥97% (TLC)
Biological Source
from parsley
Physical Property
Solubility
DMSO: soluble27 mg/mL
1 M KOH: soluble50 mg/mL
Apperance
yellow powder
Melting Point
>300 °C(lit.)
Molecule Details
Biochem/physiol Actions
A plant flavonoid that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. Inhibition of growth through cell cycle arrest and induction of apoptosis appear to be related to induction of p53.Inhibits PMA-mediated tumor promotion by inhibiting protein kinase C1 and the resulting suppression of oncogene expression. It has also been reported to inhibit topoisomerase I-catalyzed DNA re-ligation and enhance gap junctional intercellular communication.
A plant flavonoid that has been found to inhibit cell proliferation by arresting the cell cycle at the G2/M phase. Inhibition of growth through cell cycle arrest and induction of apoptosis appear to be related to induction of p53.Inhibits PMA-mediated tumor promotion by inhibiting protein kinase C1 and the resulting suppression of oncogene expression. It has also been reported to inhibit topoisomerase I-catalyzed DNA re-ligation and enhance gap junctional intercellular communication.
Molecular Spectra
No Data Available
Click here to submit data
References
No Data Available
Click here to submit data