Substance
ID:180713
Names and Identifiers
IUPAC name
2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethan-1-ol
IUPAC Traditional name
metronidazole
Synonyms
甲硝唑2-甲基-5-硝基咪唑-1-乙醇Metronidazole
Registration numbers
EC Number
CAS Number
Beilstein Number
MDL Number
PubChem SID
Properties
Product Information
Cation Traces
Pb: ≤0.001%
Zn: ≤0.0005%
Cu: ≤0.0005%
K: ≤0.005%
Mg: ≤0.0005%
Na: ≤0.005%
Al: ≤0.0005%
Ca: ≤0.005%
Fe: ≤0.0005%
Antion Traces
sulfate (SO42-): ≤0.05%
chloride (Cl-): ≤0.05%
Impurities
≤0.1% Insoluble matter
≤0.0005% Phosphorus (P)
Ignition Residue
≤0.1%
Safety Information
GHS Signal Word
Warning
RTECS
NI5600000
Safety Statements
36/37
Storage Temperature
2-8°C
Risk Statements
40
GHS Pictograms
Respiratory sensitization, category 1
Germ cell mutagenicity, categories 1A,1B,2
Carcinogenicity, categories 1A,1B,2
Reproductive toxicity, categories 1A,1B,2
Specific Target Organ Toxicity – Single exposure, categories 1,2
Specific Target Organ Toxicity – Repeated exposure, categories 1,2
Aspiration Hazard, category 1
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
German water hazard class
3
GHS Hazard statements
H351
European Hazard Symbols
Harmful (Xn)GHS Precautionary statements
P281
Physical Property
Solubility
acetic acid: soluble0.1 M, clear, faintly yellow
Melting Point
159-161 °C(lit.)
Molecule Details
Application
Metronidazole is a nitroimidazole used to treat amebiasis, vaginitis, Trichomonas infections, giardiasis, anaerobic bacteria and treponemal infections. Metronidazole is used to study DNA damage and repair and has been found to induce the gene transfer agent VSH-1 in Brachyspira hyodysenteriae. It is commonly used for treatment of periodontitis and is used in bioavailability studies.
Biochem/physiol Actions
Metronidazole induces DNA strand breaks. Metronidazole is used to study DNA damage and repair and has been found to induce the gene transfer agent VSH-1 in Brachyspira hyodysenteriae.
Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce metronidazole to its active form. Reduced metronidazole covalently binds to DNA which disrupts its helical structure, induces DNA strand breaks and inhibits bacterial nucleic acid synthesis. Bacterial cell death results.
Metronidazole is a nitroimidazole used to treat amebiasis, vaginitis, Trichomonas infections, giardiasis, anaerobic bacteria and treponemal infections. Metronidazole is used to study DNA damage and repair and has been found to induce the gene transfer agent VSH-1 in Brachyspira hyodysenteriae. It is commonly used for treatment of periodontitis and is used in bioavailability studies.
Biochem/physiol Actions
Metronidazole induces DNA strand breaks. Metronidazole is used to study DNA damage and repair and has been found to induce the gene transfer agent VSH-1 in Brachyspira hyodysenteriae.
Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce metronidazole to its active form. Reduced metronidazole covalently binds to DNA which disrupts its helical structure, induces DNA strand breaks and inhibits bacterial nucleic acid synthesis. Bacterial cell death results.
Molecular Spectra
No Data Available
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References
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