Substance
ID:180598
Names and Identifiers
IUPAC name
[2-(acetyloxy)ethyl]trimethylazanium chloride
IUPAC Traditional name
acetylcholine chloride
Synonyms
AChAcetylcholine chloride氯化乙酰胆碱
Registration numbers
CAS Number
Beilstein Number
EC Number
MDL Number
PubChem SID
Properties
Safety Information
GHS Signal Word
Warning
GHS Hazard statements
H315-H319-H335
European Hazard Symbols
Irritant (Xi)Safety Statements
26
GHS Precautionary statements
P261-P305+P351+P338
Risk Statements
36/37/38
RTECS
FZ9800000
German water hazard class
2
GHS Pictograms
Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, category 2
Eye irritation, category 2
Skin sensitisation, category 1
Specific Target Organ Toxicity – Single exposure, category 3
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Physical Property
Melting Point
146-150 °C(lit.)
Product Information
Purity
~99%
Suitability
suitable for cell culture
Molecule Details
Biochem/physiol Actions
Acetylcholine chloride, injected at 20 mg/kg body weight, reduces mortality and plasma proinflammatory cytokines in mice with experimentally-induced sepsis 1. The cholinergicanti-infl ammatory mechanism is probably mediated by interaction of acetylcholine with α7n cholinoreceptor on monocytes, macrophages, and neutrophils, which decreases the levels of proinflammatory cytokines such as TNF-α, IL-1β, and IL-6.
Acetylcholine chloride, injected at 20 mg/kg body weight, reduces mortality and plasma proinflammatory cytokines in mice with experimentally-induced sepsis 1. The cholinergicanti-infl ammatory mechanism is probably mediated by interaction of acetylcholine with α7n cholinoreceptor on monocytes, macrophages, and neutrophils, which decreases the levels of proinflammatory cytokines such as TNF-α, IL-1β, and IL-6.
Molecular Spectra
No Data Available
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References
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