Substance
ID:180559
Names and Identifiers
Synonyms
氯苯甲咪唑1-[(2-氯苯基)二苯甲基]-1H-咪唑克霉唑三苯氯甲咪唑Clotrimazole
IUPAC Traditional name
lotrimin
IUPAC name
1-[(2-chlorophenyl)diphenylmethyl]-1H-imidazole
Properties
Safety Information
European Hazard Symbols
Harmful (Xn)Risk Statements
22-36/38
GHS Signal Word
Warning
GHS Hazard statements
H302-H315-H319
German water hazard class
3
Safety Statements
26-36
GHS Precautionary statements
P305+P351+P338
RTECS
NI4377000
GHS Pictograms
Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, category 2
Eye irritation, category 2
Skin sensitisation, category 1
Specific Target Organ Toxicity – Single exposure, category 3
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Pharmacology Properties
Gene Information
human ... ABCB1(5243), CYP17A1(1586), CYP3A4(1576)mouse ... Abcb1a(18671), Abcb1b(18669)
Molecule Details
Biochem/physiol Actions
Specific inhibitor of Ca2+-activated K+ channels. Antifungal azole. Antifungal mode of action: Inhibits cytochrome P450-dependent 14α-demethylase, which is critical to ergosterol biosynthesis. The accumulated 14α-methylated sterols change the membrane structure of sensitive fungi, altering cell membrane permeability.
Specific inhibitor of Ca2+-activated K+ channels. Antifungal azole. Antifungal mode of action: Inhibits cytochrome P450-dependent 14α-demethylase, which is critical to ergosterol biosynthesis. The accumulated 14α-methylated sterols change the membrane structure of sensitive fungi, altering cell membrane permeability.
Molecular Spectra
No Data Available
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References
No Data Available
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