Substance
ID:180535
Names and Identifiers
IUPAC name
4-amino-N-(5-methoxypyrimidin-2-yl)benzene-1-sulfonamide
Synonyms
5-甲氧基磺胺嘧啶SulfameterN1-(5-甲氧基嘧啶-2-基)磺胺磺胺对甲氧嘧啶
IUPAC Traditional name
kiron
Registration numbers
CAS Number
EC Number
PubChem SID
Beilstein Number
MDL Number
Properties
Safety Information
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Storage Temperature
2-8°C
European Hazard Symbols
Irritant (Xi)German water hazard class
2
Risk Statements
36/37/38
RTECS
WP0525000
Safety Statements
26-36
GHS Pictograms
Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, category 2
Eye irritation, category 2
Skin sensitisation, category 1
Specific Target Organ Toxicity – Single exposure, category 3
GHS Signal Word
Warning
GHS Precautionary statements
P261-P305+P351+P338
GHS Hazard statements
H315-H319-H335
Molecule Details
Application
Sulfameter is a sulfonamide antibiotic used as a leprostatic agent and to treat urinary tract infections1. It has been investigated as a potential therapy for chloroquine-resistant malaria during pregnancy2.
Biochem/physiol Actions
Sulfameter is a sulfonamide antibiotic. Sulfonamides block the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase. Sulfonamides are competitive inhibitors of bacterial para-aminobenzoic acid (PABA), which is required for bacterial synthesis of folic acid3. Sulfameter is a dihydrofolate reductase (DHFR) inhibitor. Sulfonamides are active against Gram positive bacteria and Gram negative bacteria. Mode of resistance is via the alteration of dihydropteroate synthase or alternative pathway for folic acid synthesis.
Sulfameter is a sulfonamide antibiotic used as a leprostatic agent and to treat urinary tract infections1. It has been investigated as a potential therapy for chloroquine-resistant malaria during pregnancy2.
Biochem/physiol Actions
Sulfameter is a sulfonamide antibiotic. Sulfonamides block the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase. Sulfonamides are competitive inhibitors of bacterial para-aminobenzoic acid (PABA), which is required for bacterial synthesis of folic acid3. Sulfameter is a dihydrofolate reductase (DHFR) inhibitor. Sulfonamides are active against Gram positive bacteria and Gram negative bacteria. Mode of resistance is via the alteration of dihydropteroate synthase or alternative pathway for folic acid synthesis.
Molecular Spectra
No Data Available
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References
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