Substance
ID:180506
Names and Identifiers
IUPAC Traditional name
sulfamethazine sodium
IUPAC name
4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzene-1-sulfonamide sodium
Synonyms
Sulfamethazine sodium salt磺胺二甲基嘧啶 钠盐4-Amino-N-(4,6-dimethyl-2-pyrimidinyl)benzenesulfonamide
Properties
Product Information
Purity
≥98%
Safety Information
GHS Hazard statements
H302
GHS Pictograms
Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, category 2
Eye irritation, category 2
Skin sensitisation, category 1
Specific Target Organ Toxicity – Single exposure, category 3
Storage Temperature
2-8°C
Safety Statements
36
GHS Signal Word
Warning
European Hazard Symbols
Harmful (Xn)German water hazard class
3
Risk Statements
22
Molecule Details
Application
Sulfamethazine is an antibiotic used to clinically treat bronchitis, prostatitis and urinary tract infections1. It is used in disposition and depletion kinetic studies2,3. It is used to develop detection techniques for quantification in fluids such as cows’ milk, honey and swine urine4.
Biochem/physiol Actions
Sulfamethazine is an antimicrobial sulfur drug that blocks the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase. Sulfamethazine is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), which is required for bacterial synthesis of folic acid1. It induces CYP3A4 expression and is acetylated by N-acetyltransferase. It exhibits sex dependent pharmacokinetics, metabolized by the male specific isoform CYP2C11. Sulfamethazine is bacteriostatic.
Sulfamethazine is an antibiotic used to clinically treat bronchitis, prostatitis and urinary tract infections1. It is used in disposition and depletion kinetic studies2,3. It is used to develop detection techniques for quantification in fluids such as cows’ milk, honey and swine urine4.
Biochem/physiol Actions
Sulfamethazine is an antimicrobial sulfur drug that blocks the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase. Sulfamethazine is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), which is required for bacterial synthesis of folic acid1. It induces CYP3A4 expression and is acetylated by N-acetyltransferase. It exhibits sex dependent pharmacokinetics, metabolized by the male specific isoform CYP2C11. Sulfamethazine is bacteriostatic.
Molecular Spectra
No Data Available
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References
No Data Available
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