Substance
ID:180271
Names and Identifiers
IUPAC Traditional name
carbamazepine
Synonyms
5H-二苯并[b,f]氮杂卓-5-甲酰胺卡马西平Carbamazepine
IUPAC name
2-azatricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,9,11,13-heptaene-2-carboxamide
Properties
Physical Property
Solubility
ethanol: soluble
H2O: insoluble
propylene glycol: soluble
45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: soluble29 mg/mL
Apperance
powder
Melting Point
191-192 °C(lit.)
Safety Information
GHS Signal Word
Danger
GHS Hazard statements
H302-H317-H334
European Hazard Symbols
Harmful (Xn)RTECS
HN8225000
GHS Precautionary statements
P261-P280-P342+P311
Safety Statements
22-36/37/39
Risk Statements
22-42/43
German water hazard class
2
GHS Pictograms
Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, category 2
Eye irritation, category 2
Skin sensitisation, category 1
Specific Target Organ Toxicity – Single exposure, category 3
Respiratory sensitization, category 1
Germ cell mutagenicity, categories 1A,1B,2
Carcinogenicity, categories 1A,1B,2
Reproductive toxicity, categories 1A,1B,2
Specific Target Organ Toxicity – Single exposure, categories 1,2
Specific Target Organ Toxicity – Repeated exposure, categories 1,2
Aspiration Hazard, category 1
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Storage Temperature
2-8°C
Pharmacology Properties
Gene Information
human ... BZRAP1(9256), GABRA1(2554), GABRA2(2555), GABRA3(2556), GABRA4(2557), GABRA5(2558), GABRA6(2559), GABRB1(2560), GABRB2(2561), GABRB3(2562), PRNP(5621), SCN5A(6331)rat ... Scn2a1(24766), Scnn1a(25122), Scnn1g(24768), Slc6a1(79212)
Molecule Details
Biochem/physiol Actions
抗惊厥药；GABAA 受体苯二氮卓调控位点的配体。
包装
1, 5, 10, 25 g in glass bottle
抗惊厥药；GABAA 受体苯二氮卓调控位点的配体。
包装
1, 5, 10, 25 g in glass bottle
Molecular Spectra
No Data Available
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References
No Data Available
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