Substance
ID:179261
Names and Identifiers
Synonyms
1,2-Dioctanoyl-sn-glycerol1,2-Dicapryloyl-sn-glycerol(S)-Glycerol 1,2-dioctanoateD-α,β-DicaprylinDOG
IUPAC name
(2S)-1-hydroxy-3-(octanoyloxy)propan-2-yl octanoate
IUPAC Traditional name
(2S)-1-hydroxy-3-(octanoyloxy)propan-2-yl octanoate
Registration numbers
CAS Number
MDL Number
PubChem SID
Beilstein Number
Properties
Product Information
Shipped in
dry ice
Purity
≥96% (TLC)
Physical Property
Apperance
yellow oil
Solubility
DMSO: soluble
Safety Information
German water hazard class
3
RTECS
RH0764500
Storage Temperature
-20°C
Personal Protective Equipment
Eyeshields, Gloves, half-mask respirator (US), multi-purpose combination respirator cartridge (US)
Molecule Details
Caution
Some isomerization to the 1,3-isomer may occur in storage or in solution.
Other Notes
Synthetic 1,2-diglyceride of short chain fatty acid.
Biochem/physiol Actions
Cell-permeable, diacylglycerol (DAG) analog, and activator of protein kinase C (PKC). Shown to possess a lower affinity for the α isoform of PKC than for the other isoforms. Mimics the action of tumor-promoting phorbol esters, such as phorbol 12-myristate 13-acetate (PMA). Inhibits slow (L-type) Ca2+ current in rat heart cells independently of PKC activation and also inhibits the cGMP-gated channel in rod outer segments by a phosphorylation-independent mechanism.
Some isomerization to the 1,3-isomer may occur in storage or in solution.
Other Notes
Synthetic 1,2-diglyceride of short chain fatty acid.
Biochem/physiol Actions
Cell-permeable, diacylglycerol (DAG) analog, and activator of protein kinase C (PKC). Shown to possess a lower affinity for the α isoform of PKC than for the other isoforms. Mimics the action of tumor-promoting phorbol esters, such as phorbol 12-myristate 13-acetate (PMA). Inhibits slow (L-type) Ca2+ current in rat heart cells independently of PKC activation and also inhibits the cGMP-gated channel in rod outer segments by a phosphorylation-independent mechanism.
Molecular Spectra
No Data Available
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References
No Data Available
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