Substance
ID:179248
Names and Identifiers
Synonyms
反式-脱氢雄甾酮普拉睾酮去氢表雄酮脱氢异雄酮雄素-5-烯-3β-醇-17-酮DHEA3β-羟基-5-雄烯-17-酮trans-Dehydroandrosterone
IUPAC Traditional name
dehydroepiandrosterone
IUPAC name
(1S,2R,5S,10R,11S,15S)-5-hydroxy-2,15-dimethyltetracyclo[8.7.0.02,7.011,15]heptadec-7-en-14-one
Registration numbers
Beilstein Number
CAS Number
MDL Number
EC Number
PubChem SID
Properties
Safety Information
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Drug Control
Home Office Schedule 4.2regulated under CDSA - not available from Sigma-Aldrich Canada
GHS Precautionary statements
P261-P305+P351+P338
GHS Signal Word
Warning
Risk Statements
36/37/38
GHS Hazard statements
H315-H319-H335
European Hazard Symbols
Irritant (Xi)Safety Statements
26-36
German water hazard class
2
GHS Pictograms
Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, category 2
Eye irritation, category 2
Skin sensitisation, category 1
Specific Target Organ Toxicity – Single exposure, category 3
RTECS
BV8396000
Pharmacology Properties
Gene Information
human ... GABRA1(2554), GABRA2(2555), GABRA3(2556), GABRA4(2557), GABRA5(2558), GABRA6(2559), GABRB1(2560), GABRB2(2561), GABRB3(2562), SERPINA6(866)rat ... Ar(24208)
Physical Property
Melting Point
149-151 °C(lit.)
Product Information
Purity
≥99%
Molecule Details
Biochem/physiol Actions
Dehydroandrosterone (DHEA) is a negative modulator of GABAA receptors. It is a steroid secreted by the adrenal gland with both estrogenic and androgenic properties. DHEAs conversion to 5-androstenediol, a potent estrogen, enhances the growth and survival of estrogen-sensitive breast tumors.
Negative modulator of GABAA receptors. Steroid secreted by the adrenal gland with both estrogenic and androgenic properties. Its conversion to 5-androstenediol, a potent estrogen, enhances the growth and survival of estrogen-sensitive breast tumors. At high but physiologically valid concentrations, DHEA inhibits proliferation of chromaffin progenitor cells and induces dopaminergic differentiation.
Dehydroandrosterone (DHEA) is a negative modulator of GABAA receptors. It is a steroid secreted by the adrenal gland with both estrogenic and androgenic properties. DHEAs conversion to 5-androstenediol, a potent estrogen, enhances the growth and survival of estrogen-sensitive breast tumors.
Negative modulator of GABAA receptors. Steroid secreted by the adrenal gland with both estrogenic and androgenic properties. Its conversion to 5-androstenediol, a potent estrogen, enhances the growth and survival of estrogen-sensitive breast tumors. At high but physiologically valid concentrations, DHEA inhibits proliferation of chromaffin progenitor cells and induces dopaminergic differentiation.
Molecular Spectra
No Data Available
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References
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