Substance
ID:178788
Names and Identifiers
IUPAC name
bis(propan-2-yl) fluorophosphonate
IUPAC Traditional name
isoflurophate
Synonyms
DFP氟磷酸二异丙酯二异丙基氟磷酸酯DIFP氟代磷酸二异丙酯Diisopropylfluorophosphate
Registration numbers
CAS Number
PubChem SID
MDL Number
Beilstein Number
EC Number
Properties
Safety Information
RID/ADR
UN 3382 6.1/PG 1
GHS Pictograms
Acute toxicity (oral, dermal, inhalation), categories 1,2,3
Personal Protective Equipment
Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
RTECS
TE5075000
Hazard Class
6.1
Storage Temperature
2-8°C
German water hazard class
3
GHS Precautionary statements
P260-P264-P280-P284-P301+P310-P302+P350
UN Number
3382
Packing Group
1
European Hazard Symbols
Highly toxic (T+)GHS Signal Word
Danger
GHS Hazard statements
H300+H310+H330
Risk Statements
26/27/28
Safety Statements
36/37/39-45
Physical Property
Vapor Pressure
0.58 mmHg ( 20 °C)
Refractive Index
n20/D 1.385(lit.)
Boiling Point
62 °C/9 mmHg(lit.)
Solubility
anhydrous isopropanol: soluble0.1-0.5 M (stable for months if stored at -70 °C)
H2O: soluble1.5% at 25 °C (very unstable (at pH 7.5, half-life = 1 hr); decomposed by alkali.)
Density
1.06 g/mL at 25 °C(lit.)
Melting Point
-82 °C(lit.)
Pharmacology Properties
Gene Information
human ... PTGS1(5742), PTGS2(5743)
Molecule Details
Analysis Note
使用浓度通常为 0.10mM。苯甲基磺酰氟 (PMSF) 是一种更安全的丝氨酸蛋白酶替代抑制剂。
Other Notes
Stored properly at 2-8°C, in an unopened bottle, DIFP should be stable for a minimum of two years. DIFPis unstable when exposed to moisture. DIFP will develop a dark yellow color upon decomposition.
Biochem/physiol Actions
丝氨酸蛋白酶（如胰蛋白酶和胰凝乳蛋白酶）和乙酰胆碱酯酶的强效抑制剂；还抑制组织蛋白酶 G、胆碱脂酶、凝血因子 Xa、白细胞弹性蛋白酶、胰弹性蛋白酶、组织激肽释放酶、血纤维蛋白熔酶、枯草杆菌蛋白酶以及凝血酶。乙酰胆碱酯酶的抑制作用使该化合物具有特别强的毒性。抑制由篦麻毒素和细菌毒素诱导的细胞凋亡。
使用浓度通常为 0.10mM。苯甲基磺酰氟 (PMSF) 是一种更安全的丝氨酸蛋白酶替代抑制剂。
Other Notes
Stored properly at 2-8°C, in an unopened bottle, DIFP should be stable for a minimum of two years. DIFPis unstable when exposed to moisture. DIFP will develop a dark yellow color upon decomposition.
Biochem/physiol Actions
丝氨酸蛋白酶（如胰蛋白酶和胰凝乳蛋白酶）和乙酰胆碱酯酶的强效抑制剂；还抑制组织蛋白酶 G、胆碱脂酶、凝血因子 Xa、白细胞弹性蛋白酶、胰弹性蛋白酶、组织激肽释放酶、血纤维蛋白熔酶、枯草杆菌蛋白酶以及凝血酶。乙酰胆碱酯酶的抑制作用使该化合物具有特别强的毒性。抑制由篦麻毒素和细菌毒素诱导的细胞凋亡。
Molecular Spectra
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References
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