Substance
ID:177671
Names and Identifiers
IUPAC name
(2S,3S)-1,4-disulfanylbutane-2,3-diol
Synonyms
DTT克莱兰氏试剂DL-二硫苏糖醇1,4-二巯基苏糖醇DL-Dithiothreitol
IUPAC Traditional name
dithiothreitol
Registration numbers
MDL Number
Beilstein Number
CAS Number
EC Number
PubChem SID
Properties
Safety Information
GHS Pictograms
Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, category 2
Eye irritation, category 2
Skin sensitisation, category 1
Specific Target Organ Toxicity – Single exposure, category 3
Storage Temperature
2-8°C
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
GHS Hazard statements
H302-H315-H319-H335
Safety Statements
26-36
European Hazard Symbols
Harmful (Xn)GHS Signal Word
Warning
Risk Statements
22-36/37/38
German water hazard class
3
GHS Precautionary statements
P261-P305+P351+P338
RTECS
EK1610000
Physical Property
Flash Point
113 °C
235.4 °F
Melting Point
41-44 °C(lit.)
Product Information
Purity
≥98% (TLC)
≥99.0% (titration)
Quality Level
PREMIUM
Molecule Details
Application
用于将 -SH 基保持在还原态的绝佳试剂；定量还原二硫化物。在 SDS-PAGE 前，DTT 在样品缓冲液中可有效还原蛋白二硫键。DTT 还可用于还原交联剂 N,N′-双(丙烯酰)胱胺的二硫键桥以分解聚丙烯酰胺凝胶基质。DTT 的刺激性和毒性都低于 2-巯基乙醇。通常，使用 DTT (100mM) 所需的浓度是使用 2-巯基乙醇 (5% v/v, 700mM) 的浓度的七分之一。
包装
1 kg in poly drum
1, 5, 10, 25, 100 g in poly bottle
用于将 -SH 基保持在还原态的绝佳试剂；定量还原二硫化物。在 SDS-PAGE 前，DTT 在样品缓冲液中可有效还原蛋白二硫键。DTT 还可用于还原交联剂 N,N′-双(丙烯酰)胱胺的二硫键桥以分解聚丙烯酰胺凝胶基质。DTT 的刺激性和毒性都低于 2-巯基乙醇。通常，使用 DTT (100mM) 所需的浓度是使用 2-巯基乙醇 (5% v/v, 700mM) 的浓度的七分之一。
包装
1 kg in poly drum
1, 5, 10, 25, 100 g in poly bottle
Molecular Spectra
No Data Available
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References
No Data Available
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