Substance
ID:177471
Names and Identifiers
Synonyms
咖啡因1,3,7-三甲基黄嘌呤Caffeine
IUPAC Traditional name
caffeine
IUPAC name
1,3,7-trimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione
Registration numbers
MDL Number
Beilstein Number
CAS Number
PubChem SID
EC Number
Properties
Physical Property
Melting Point
234-236.5 °C(lit.)
Safety Information
RTECS
EV6475000
Hazard Class
6.1
GHS Hazard statements
H302
GHS Signal Word
Warning
GHS Pictograms
Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, category 2
Eye irritation, category 2
Skin sensitisation, category 1
Specific Target Organ Toxicity – Single exposure, category 3
UN Number
1544
Risk Statements
22
German water hazard class
1
European Hazard Symbols
Harmful (Xn)RID/ADR
UN 1544 6.1/PG 3
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Packing Group
3
Product Information
Packaging
vial of 250 mg
Grade
Sigma Reference Standard
Pharmacology Properties
Gene Information
human ... ADORA1(134), ADORA2B(136), ADORA3(140), PDE4B(5142)mouse ... Adora2b(11541)rat ... Adora1(29290), Adora2a(25369)
Molecule Details
包装
棕色螺旋盖样品瓶包装
Biochem/physiol Actions
一种据信是通过腺苷受体和单胺类神经递质发挥作用的中枢神经系统兴奋剂。它为腺苷受体拮抗剂和腺苷3′，5′-环单磷酸 (cAMP) 磷酸二酯酶抑制剂。因此，在用咖啡因处理后，细胞内 cAMP 的水平将升高。据报道，它会影响细胞的钙水平，从而使细胞内的钙离子外流。它会使多种化学物质(例如蛋白酶抑制剂)的细胞周期效应无效，从而防止细胞凋亡;同时，还发现它可以抑制细胞的 DNA 修复机制。
Other Notes
Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. C1778.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.
棕色螺旋盖样品瓶包装
Biochem/physiol Actions
一种据信是通过腺苷受体和单胺类神经递质发挥作用的中枢神经系统兴奋剂。它为腺苷受体拮抗剂和腺苷3′，5′-环单磷酸 (cAMP) 磷酸二酯酶抑制剂。因此，在用咖啡因处理后，细胞内 cAMP 的水平将升高。据报道，它会影响细胞的钙水平，从而使细胞内的钙离子外流。它会使多种化学物质(例如蛋白酶抑制剂)的细胞周期效应无效，从而防止细胞凋亡;同时，还发现它可以抑制细胞的 DNA 修复机制。
Other Notes
Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. C1778.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.
Molecular Spectra
No Data Available
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References
No Data Available
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