Substance
ID:177432
Names and Identifiers
IUPAC Traditional name
isoniazid
Synonyms
INH雷米封异烟酸肼Isoniazid异烟肼
IUPAC name
pyridine-4-carbohydrazide
Registration numbers
CAS Number
PubChem SID
MDL Number
EC Number
Beilstein Number
Properties
Safety Information
German water hazard class
3
GHS Pictograms
Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, category 2
Eye irritation, category 2
Skin sensitisation, category 1
Specific Target Organ Toxicity – Single exposure, category 3
Risk Statements
22-38
Safety Statements
37
GHS Signal Word
Warning
GHS Hazard statements
H302-H315
European Hazard Symbols
Harmful (Xn)Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
RTECS
NS1751850
Physical Property
Fluorescence
λex 360 nm; λem 450 nm (thiol adduct)
Melting Point
171-173 °C(lit.)
Product Information
Purity
≥99% (TLC)
Molecule Details
Biochem/physiol Actions
针对结核菌的抗生素，抑制分枝菌酸的生物合成。由肝脏 N-乙酰转移酶 (NAT) 和 细胞色素 P450 2E1 (CYP2E1) 代谢形成肝毒素。选择性诱导 CYP2E1 的表达。可逆抑制 CYP2C19 和 CYP3A4 的活性，在临床相关浓度下机械性地灭活 CYP1A2、CYP2A6、CYP2C19 和 CYP3A4。
包装
5, 50, 250 g in poly bottle
针对结核菌的抗生素，抑制分枝菌酸的生物合成。由肝脏 N-乙酰转移酶 (NAT) 和 细胞色素 P450 2E1 (CYP2E1) 代谢形成肝毒素。选择性诱导 CYP2E1 的表达。可逆抑制 CYP2C19 和 CYP3A4 的活性，在临床相关浓度下机械性地灭活 CYP1A2、CYP2A6、CYP2C19 和 CYP3A4。
包装
5, 50, 250 g in poly bottle
Molecular Spectra
No Data Available
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References
No Data Available
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