Substance

ID:177295

Names and Identifiers
IUPAC name
9-methoxy-7H-furo[3,2-g]chromen-7-one
Synonyms
8-MOP9-甲氧基呋喃并[3,2-g][1]苯并吡喃-7-酮甲氧沙林8-甲氧基补骨脂素花椒毒内酯8-Methoxypsoralen花椒毒素
IUPAC Traditional name
methoxsalen
Registration numbers
EC Number
206-066-9
Beilstein Number
196453
CAS Number
298-81-7
MDL Number
MFCD00005009
PubChem SID
24896845
Properties
Safety Information
GHS Signal Word
Danger
GHS Precautionary statements
P261-P342+P311
Safety Statements
36/37
GHS Pictograms
GHS07
Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, category 2
Eye irritation, category 2
Skin sensitisation, category 1
Specific Target Organ Toxicity – Single exposure, category 3
GHS08
Respiratory sensitization, category 1
Germ cell mutagenicity, categories 1A,1B,2
Carcinogenicity, categories 1A,1B,2
Reproductive toxicity, categories 1A,1B,2
Specific Target Organ Toxicity – Single exposure, categories 1,2
Specific Target Organ Toxicity – Repeated exposure, categories 1,2
Aspiration Hazard, category 1
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Risk Statements
22-43
European Hazard Symbols
Harmful Harmful (Xn)
RTECS
LV1400000
German water hazard class
3
GHS Hazard statements
H302-H334
Physical Property
Solubility
acetic acid: soluble
H2O: slightly soluble
Apperance
white to yellow powder
Melting Point
148-150 °C(lit.)
Pharmacology Properties
Gene Information
rat ... Maoa(29253)
Molecule Details
Biochem/physiol Actions
8-甲氧基补骨脂素 (8-MOP) 加 A 波紫外线 (UVA) 辐射可诱导单加合物形成和 DNA 链间交联，因此可用于研究 DNA 修复和重组机制。培养的正常人黑素细胞经 8-甲氧基补骨脂素处理和 A 波紫外线 (UVA) 照射后形成 8-甲氧基补骨脂素-磷脂光加成产物，经二酰甘油取代后可在无细胞体系中激活蛋白激酶 C。8-MOP 是纯化重组细胞色素 P450 的灭活剂。它还可以通过抑制 [Ca2+] 的升高，而抑制从 P 物质激活的大鼠腹膜肥大细胞的 P 物质诱导型组胺释放。
Caution
避光。
包装
1, 5 g in glass bottle
Molecular Spectra
No Data Available
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References
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