at least 40 to 50%

urine, and to a lesser extent in feces

2 to 3 days (average in one study 55 hours)

hepatic, by cytochrome P450, isoenzymes 3A, and 1A2; metabolites are inactive

oral only

Rx-only, not a controlled narcotic

Teratogenic data in rats exist : drug should only be used when the benefit clearly exceeds the potential harm to the unborn