Substance

ID:170905

Names and Identifiers
Synonyms
Clozapine
Brand Name
Clozaril
IUPAC name
6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatricyclo[9.4.0.03,8]pentadeca-1(11),3,5,7,9,12,14-heptaene
IUPAC Traditional name
clozapine
Registration numbers
PubChem CID
2818
CAS Number
5786-21-0
IUPHAR ligand ID
38
ATC CODE
N05AH02
CHEMBL
42
DrugBank ID
DB00363
CHEBI ID
3766
KEGG ID
D00283
Medline Plus
a691001
Unique Ingredient Identifier
J60AR2IKIC
Chemspider ID
10442628
Wikipedia Title
Clozapine
Properties
Pharmacology Properties
Metabolism
Hepatic, by several CYP isozymes
Half Life
6 to 26 hours (mean value 14.2 hours in steady state conditions)
Pregnancy Category
B
Admin Routes
Oral
Excretion
80% in metabolized state: 30% biliary and 50% renal
Legal Status
Prescription only, special restrictions imposed in many countries
Bioavailability
60 to 70%
Physical Property
Melting Point
183°C (361.4°F)
Solubility
0.1889 mg/mL (20°C) in water
Molecule Details
Molecular Spectra
No Data Available
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References
No Data Available
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