16 to 30 hours. In long term treatment, CPZ induces its own metabolism

C—only when benefit for the mother exceeds risk to unborn child

Biliary and renal, as metabolites (only traces of unchanged drug)

Oral, rectal (suppository), IM, IV infusion

Hepatic, mostly CYP2D6-mediated

Oral, 30 to 50% (interindividual variations 10–70%)

Rx-only