Odorless, white needles or powder

2.17 g/100 mL (25 °C)
18.0 g/100 mL (80 °C)
67.0 g/100 mL (100 °C) in water

227–228 °C, 500-501 K (anhydrous)
234–235 °C, 507-508 K (monohydrate)

178°C (subl.)

3.64 D (calculated)

1.23 g/cm³, solid

-0.13–1.22 protonated caffeine

Harmful (Xn)

S2

192 mg/kg (rat, oral)

EV6475000

613-086-00-5

R22

C (US)

urine (100%)

99%

17% to 36%

Oral, insufflation, enema

OTC (US)

unscheduled (Australia)

GSL (UK)

demethylation by CYP1A2

5 hours

Moderate