Substance
ID:1450
Names and Identifiers
IUPAC name
5-amino-[1,2,3]triazolo[4,5-d]pyrimidin-7-ol
Synonyms
8-Azaguanine
IUPAC Traditional name
@8-azaguanine
Registration numbers
CAS Number
Properties
Physical Property
Solubility
Insoluble
Hydrophobicity(logP)
-0.71 [HANSCH,C ET AL. (1995)]
Molecule Details
Drug Groups
experimental
Description
One of the early purine analogs showing antineoplastic activity. It functions as an antimetabolite and is easily incorporated into ribonucleic acids. [PubChem]
References
•
Tong, George L.; Lee, William W.; Goodman, Leon; Frederiksen, Sune (1965). "Synthesis of some 2′-deoxyribosides of 8-azaadenine". Archives of Biochemistry and Biophysics (University of California: Elsevier) 112 (1): 76. "http://dx.doi.org/10.1016/0003-9861(65)90012-3":http://dx.doi.org/10.1016/0003-9861(65)90012-3
•
Michels AW, Ostrov DA, Zhang L, Nakayama M, Fuse M, McDaniel K, Roep BO, Gottlieb PA, Atkinson MA, Eisenbarth GS: Structure-based selection of small molecules to alter allele-specific MHC class II antigen presentation. J Immunol. 2011 Dec 1;187(11):5921-30. Epub 2011 Oct 31.
[Pubmed]
External Links
Molecular Spectra
No Data Available
Click here to submit data
References
• Michels AW, Ostrov DA, Zhang L, Nakayama M, Fuse M, McDaniel K, Roep BO, Gottlieb PA, Atkinson MA, Eisenbarth GS: Structure-based selection of small molecules to alter allele-specific MHC class II antigen presentation. J Immunol. 2011 Dec 1;187(11):5921-30. Epub 2011 Oct 31. Pubmed
• Tong, George L.; Lee, William W.; Goodman, Leon; Frederiksen, Sune (1965). "Synthesis of some 2′-deoxyribosides of 8-azaadenine". Archives of Biochemistry and Biophysics (University of California: Elsevier) 112 (1): 76. "http://dx.doi.org/10.1016/0003-9861(65)90012-3":http://dx.doi.org/10.1016/0003-9861(65)90012-3