Substance
ID:141
Names and Identifiers
Brand Name
Acronize PDAureocarmylAureociclinAurofac 10ChrysomykineFlamycinAureomycin hydrochlorideBiomycin ABiomycin hydrochlorideBiovetinIsphamycinOrosprayTocopherexAureociclinaAureocyclineAureomicinaAureomycin monohydrochlorideAuxeomycinB-AureoCentraureoClorocipanTetrlysal 300AureomycinAureocinaAureomykoinBiomitsinBiomitsin hydrochlorideChrusomykineDuomycinTetralysalPsittacin hydrochlorideTetra 5AcronizeAureomycin A-377Aurofac
Synonyms
Chlortetracyclinium chlorideChlortetracyclineChlortetracyclin7-ChlorotetracyclineChlorotetracycline hydrochlorideCLTCLymecyclineChlorotetracyclineChlortetracycline hydrochloride
IUPAC Traditional name
limeciclina
IUPAC name
(2S)-6-[({[(4S,4aS,5aS,6S,12aS)-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracen-2-yl]formamido}methyl)amino]-2-aminohexanoic acid
Properties
Physical Property
Hydrophobicity(logP)
0.3
Solubility
Soluble (at all physiological pH values)
Molecule Details
Drug Groups
approved
Description
A tetracycline with a 7-chloro substitution. [PubChem]
Indication
For the treatment of infections and to treat acne. It may also be used to treat urinary tract infections, gum disease, and other bacterial infections such as gonorrhea and chlamydia. Lymecycline is also used commonly as a prophylactic treatment for infection by Bacillus anthracis (anthrax). It is also effective against Yersinia pestis and malaria and is also prescribed for the treatment of Lyme disease.
Pharmacology
Lymecycline is a tetracycline broad-spectrum antibiotic. It is approximately 5000 times more soluble than tetracycline base and is unique amongst tetracyclines in that it is absorbed by the "active transport" process across the intestinal wall, making use of the same fast and efficient mechanism by which carbohydrates are absorbed. It inhibits cell growth by inhibiting translation.
Toxicity
Adverse effects include nausea, vomiting, diarrhoea, glossitis, enterocolitis, dysphagia, dermatitis, hypersensitivity reactions, proctitis, and vaginitis.
Affected Organisms
Enteric bacteria and other eubacteria
Absorption
Absorption is fast and efficient. Bioavailability is 100% following oral administration.
References
External Links
Molecular Spectra
No Data Available
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