Substance
ID:130939
Names and Identifiers
Synonyms
Ac-Ile-Glu-Pro-Asp-paranitroanilideAc-IEPD-PNAAc-Ile-Glu-Pro-Asp-PNA
IUPAC Traditional name
(4S)-5-[(2S)-2-{[(1S)-2-carboxy-1-[(4-nitrophenyl)carbamoyl]ethyl]carbamoyl}pyrrolidin-1-yl]-4-[(2S,3S)-2-acetamido-3-methylpentanamido]-5-oxopentanoic acid
IUPAC name
(4S)-5-[(2S)-2-{[(1S)-2-carboxy-1-[(4-nitrophenyl)carbamoyl]ethyl]carbamoyl}pyrrolidin-1-yl]-4-[(2S,3S)-2-acetamido-3-methylpentanamido]-5-oxopentanoic acid
Registration numbers
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Properties
Safety Information
MSDS Link
Product Information
Certificate of Analysis
Molecule Details
A colorimetric substrate for Granzyme B (Kcat/Km = 66000 M-1s-1). Cleavage of pNA is monitored colorimetrically at ~405 nm (e = 9,160 M-1cm-1).
Molecular Spectra
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References
• Harris, J.L. et al., J. Biol. Chem., 273:27364 (1998).
• Thornberry, N.A. et al., Science, 281:1312 (1998).