Substance
ID:130930
Names and Identifiers
IUPAC Traditional name
(3S)-3-[(2S)-2-[(2S)-2-[(2S)-2-acetamido-3-(4-hydroxyphenyl)propanamido]-3-methylbutanamido]propanamido]-3-[(4-nitrophenyl)carbamoyl]propanoic acid
IUPAC name
(3S)-3-[(2S)-2-[(2S)-2-[(2S)-2-acetamido-3-(4-hydroxyphenyl)propanamido]-3-methylbutanamido]propanamido]-3-[(4-nitrophenyl)carbamoyl]propanoic acid
Synonyms
Ac-Tyr-Val-Ala-Asp-PNAAc-Tyr-Val-Ala-Asp-paranitroanilideAc-Y-V-A-D-PNA
Registration numbers
No Data Available
Click here to submit data
Properties
Product Information
Certificate of Analysis
Safety Information
MSDS Link
Molecule Details
A colorimetric substrate for Caspase-1. Sequence is based on the caspase-1 cleavage site of the IL-1b precursor and includes Asp116. Also a substrate for caspase-4. Cleavage of pNA is monitored colorimetrically at ~405 nm (e = 9,160 M-1cm-1).
Molecular Spectra
No Data Available
Click here to submit data
References
• Thornberry, N.A., et al. 1994. Methods Enzymol. 244, 615.
• Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
• Reiter, L.A. 1994. Int. J. Pept. Protein Res. 43, 87.
• Marcelli, M. et al., Cancer Res., 58:76 (1998).
• Thornberry, N.A., et al. 1992. Nature 356, 768.