Substance
ID:130929
Names and Identifiers
Synonyms
MeOSuc-Ala-Ala-Pro-Val-paranitroanilideMeOSuc-Ala-Ala-Pro-Val-PNAMeOSuc-AAPV-PNA
IUPAC name
methyl 3-{[(1S)-1-{[(2S)-1-[(2S)-2-{[(1S)-2-methyl-1-[(4-nitrophenyl)carbamoyl]propyl]carbamoyl}pyrrolidin-1-yl]-1-oxopropan-2-yl]carbamoyl}ethyl]carbamoyl}propanoate
IUPAC Traditional name
methyl 3-{[(1S)-1-{[(2S)-1-[(2S)-2-{[(1S)-2-methyl-1-[(4-nitrophenyl)carbamoyl]propyl]carbamoyl}pyrrolidin-1-yl]-1-oxopropan-2-yl]carbamoyl}ethyl]carbamoyl}propanoate
Registration numbers
CAS Number
Properties
Safety Information
MSDS Link
Product Information
Certificate of Analysis
Molecule Details
A specific chromogenic substrate for human neutrophil elastase (Kcat/Km = 120,000 vs. 2700 for pancreatic elastase). Cleavage can be monitored at ~410 nm. Sold on the basis of substrate content.
Molecular Spectra
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References
• Thornberry, N.A. et al., J. Biol. Chem., 272:17907 (1997).
• Thornberry, N.A. et al., Science, 281:1312 (1998).
• Barrett, A.J., et al. 1989. Biochim. J. 260, 259.
• Nakajima, K., et al. 1979. J. Biol. Chem. 254, 4027.