Substance
ID:130900
Names and Identifiers
Synonyms
Q-Ala-Glu(OMe)-Val-Asp(OMe)-OPHQuinoline-Ala-Glu(OMe)-Val-Asp(OMe)-DifluorophenoxymethylketoneQ-AE(OMe)VD(OMe)-OPH
IUPAC name
methyl (3S)-5-(2,6-difluorophenoxy)-3-[(2S)-2-[(2S)-5-methoxy-5-oxo-2-[(2S)-2-(quinolin-2-ylformamido)propanamido]pentanamido]-3-methylbutanamido]-4-oxopentanoate
IUPAC Traditional name
methyl (3S)-5-(2,6-difluorophenoxy)-3-[(2S)-2-[(2S)-5-methoxy-5-oxo-2-[(2S)-2-(quinolin-2-ylformamido)propanamido]pentanamido]-3-methylbutanamido]-4-oxopentanoate
Registration numbers
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Properties
Safety Information
MSDS Link
Product Information
Certificate of Analysis
Molecule Details
A potent, cell-permeable, and irreversible inhibitor of Group III caspases (caspase-6, caspase-8, caspase-9, and caspase-10), although more effective towards caspases-6 and -8. Also inhibits caspase-1 and caspase-3. When using with purified native or recombinant enzyme, pretreatment with an esterase is required.
Molecular Spectra
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References
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