Substance
ID:130823
Names and Identifiers
IUPAC Traditional name
benzyl N-[(1S)-1-{[(2S)-4-fluoro-3-oxobutan-2-yl]carbamoyl}-2-phenylethyl]carbamate
Synonyms
Z-Phe-Ala-FMKZ-FA-FMKZ-Phe-Ala-Fluoromethylketone
IUPAC name
benzyl N-[(1S)-1-{[(2S)-4-fluoro-3-oxobutan-2-yl]carbamoyl}-2-phenylethyl]carbamate
Registration numbers
CAS Number
Properties
Safety Information
MSDS Link
Product Information
Certificate of Analysis
Molecule Details
A cell-permeable, irreversible cathepsin B inhibitor. Blocks LPS-induced production of IL-1a and IL-1b. Suitable as a negative control for caspase-1 and caspase-2 inhibitors because it lacks an aspartic acid residue at the P1 position.
Molecular Spectra
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References
• Ahmed, N.K., et al. 1992. Biochem. Pharmacol. 44, 1201.
• Schotte, P., et al. 2001. J. Biol. Chem. 276, 21153.
• Rosenthal, P.J., et al. 1993. J. Clin. Invest. 91, 1057.
• Rauber, P., et al. 1986. Biochem. J. 239, 633.
• Shaw, E., et al. 1986. Biomed. Biochim. Acta 45, 1397.
• Rasnick, D. 1985. Anal. Biochem. 149, 461.
• Farber, A. et al., J. Vasc. Surg., 30(4):752 (1999).
• Guo, H., et al. 1998. Exp. Cell Res. 245, 57.